ILT4 (Protein | Antibody | cDNA Clone | ELISA Kit)

All ILT4 reagents are produced in house and quality controlled, including 5 ILT4 Antibody, 13 ILT4 Gene, 2 ILT4 Lysate, 3 ILT4 Protein, 1 ILT4 qPCR. All ILT4 reagents are ready to use.

ILT4 Protein (3)

ILT4 Antibody (5)

ILT4 cDNA Clone (13)

BC036827

ILT4 qPCR Primer (1)

ILT4 Lysate (2)

ILT4 Background

ILT4, also known as LILRB2, is a member of the the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). ILT4 gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. Multiple transcript variants encoding different isoforms have been found for ILT4 gene. ILT4 is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.

ILT4 References

  • Colonna M., et al.,(1997), A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J. Exp. Med. 186:1809-1818.
  • Borges L., et al., (1997), A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.J. Immunol. 159:5192-5196.
  • Grimwood J., et al.,(2004), The DNA sequence and biology of human chromosome 19.Nature 428:529-535.