ALK-1 Matched ELISA Antibody Pair Set,Human

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ALK-1 Matched ELISA Antibody Pair Set,Human General Information

Product name
ALK-1 Matched ELISA Antibody Pair Set,Human
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Human ALK-1
Assay range
15.63-1000 pg/mL
Materials provided
1. Capture Antibody 1.0 mg/mL of rabbit anti-ALK1 monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 10066-R104)
2. Detection Antibody 0.2 mg/mL rabbit anti-ALK1 monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.5 μg/mL in detection antibody dilution buffer before use. (Catalog: # 10066-R024)
3. Standard Each vial contains 60 ng of recombinant ALK1. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 1 ng/mL is recommended.
Product overview
This ALK-1 Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human ALK-1 . It contains Human ALK-1 capture antibody, Human ALK-1 detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human ALK-1 protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

ALK-1 Matched ELISA Antibody Pair Set,Human Images

ALK-1 Matched ELISA Antibody Pair Set,Human: Alternative Names

ACVRLK1 Matched ELISA Antibody Pair Set, Human; ALK-1 Matched ELISA Antibody Pair Set, Human; ALK1 Matched ELISA Antibody Pair Set, Human; HHT Matched ELISA Antibody Pair Set, Human; HHT2 Matched ELISA Antibody Pair Set, Human; ORW2 Matched ELISA Antibody Pair Set, Human; SKR3 Matched ELISA Antibody Pair Set, Human; TSR-I Matched ELISA Antibody Pair Set, Human

ALK-1 Background Information

Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
Full Name
activin A receptor type II-like 1
References
  • French Rendu-Osler network,et al. (2004) Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France. Hum Mutat. 23(4): 289-299.
  • Simon M, et al. (2006) Association of a polymorphism of the ACVRL1 gene with sporadic arteriovenous malformations of the central nervous system. J Neurosurg. 104(6): 945-9.
  • Argyriou L, et al. (2006) Novel mutations in the ENG and ACVRL1 genes causing hereditary hemorrhagic teleangiectasia. Int J Mol Med. 17(4):655-9.
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