HGF Activator / HGFA (Protein | Antibody | cDNA Clone | ELISA Kit)

All HGF Activator / HGFA reagents are produced in house and quality controlled, including 4 HGF Activator / HGFA Antibody, 26 HGF Activator / HGFA Gene, 1 HGF Activator / HGFA Lysate, 1 HGF Activator / HGFA Protein, 2 HGF Activator / HGFA qPCR. All HGF Activator / HGFA reagents are ready to use.

HGF Activator / HGFA Related Research Area

HGF Activator / HGFA Background

HGF activator (HGFA) is a serum-derived serine protease and belongs to the peptidase family S1.HGFA is responsible for the conversion of hepatocyte growth factor (HGF), from the inactive single-chain precursor to the active heterodimeric form, which is a potent mitogen, motogen, and morphogen for liver cells, epithelial cells, and endothelial cells. HGFA is synthesized and secreted by the liver and circulates in the plasma as an inactive single-chain zymogen in normal states. The zymogen is cleaved by thrombin or thermolysin through the endoproteolytic process and forms an active heterodimer linked by a disulfide bond. In turn, the active protease can be inhibited by HGFA inhibitors (HAIs) including HAI-1 and HAI-2. In addition, the HGFA zymogen acquires a strong affinity upon activation and thus may ensure the local action in tissue regeneration in liver, kidney and skin. It has been reported that activation of HGF is a critical limiting step in the HGF/SF-induced signaling pathway mediated by Met, and accordingly, aberrant expression of HGFA is implicated in tumorigenesis and progression.

HGF Activator / HGFA References

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    2.  Miyazawa, K. et al., 1996, J. Biol. Chem. 271 : 3615-3618.

    3.  Shia, S. et al., 2005, J. Mol. Biol. 346: 1335-1349.

    4.  Kataoka, H. et al., 2000, J. Biol. Chem. 275: 40453-40462.

    5.  Tjin, E.P. et al., 2006, Blood. 107: 760-768.

    6.  Kitajima, Y. et al., 2000, Cancer. Res. 60: 6148-6159.