GFR Alpha-2 / GFRA2 (Protein | Antibody | cDNA Clone | ELISA Kit)

All GFR Alpha-2 / GFRA2 reagents are produced in house and quality controlled, including 4 GFR Alpha-2 / GFRA2 Antibody, 39 GFR Alpha-2 / GFRA2 Gene, 2 GFR Alpha-2 / GFRA2 Lysate, 2 GFR Alpha-2 / GFRA2 Protein, 3 GFR Alpha-2 / GFRA2 qPCR. All GFR Alpha-2 / GFRA2 reagents are ready to use.

GFR Alpha-2 / GFRA2 Protein (2)

    GFR Alpha-2 / GFRA2 Antibody (4)

      GFR Alpha-2 / GFRA2 cDNA Clone (39)

      NM_001495.4
      NM_008115.2
      NM_012750.1

      GFR Alpha-2 / GFRA2 Lysate (2)

        GFR Alpha-2 / GFRA2 Background

        GFRA2 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA2 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA/GDNFRa acts as the ligand-binding component. Experiments have improved that GFRA2 genetic variants and age may play a role in Tardive dyskinesia (TD) susceptibility, but further work is required to confirm these findings.

        GFR Alpha-2 / GFRA2 References

        • Jing S, et al. (1997) GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family. J Biol Chem. 272(52): 33111-7.
        • Souza RP, et al. (2010) Glial cell line-derived neurotrophic factor receptor alpha 2 (GFRA2) gene is associated with tardive dyskinesia. Psychopharmacology. 210(3): 347-54.
        • Vanhorne JB, et al. (2001) Cloning and characterization of the human GFRA2 locus and investigation of the gene in Hirschsprung disease. Hum Genet. 108(5): 409-15.