P38 Gamma / MAPK12 (Protein | Antibody | cDNA Clone | ELISA Kit)

All P38 Gamma / MAPK12 reagents are produced in house and quality controlled, including 1 P38 Gamma / MAPK12 Antibody, 1 P38 Gamma / MAPK12 Gene, 1 P38 Gamma / MAPK12 IP Kit, 2 P38 Gamma / MAPK12 Lysate, 2 P38 Gamma / MAPK12 Protein. All P38 Gamma / MAPK12 reagents are ready to use.

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P38 Gamma / MAPK12 Background

ERK3, also known as MAPK12 and p38-gamma, belongs to theprotein kinase superfamily, CMGC Ser/Thr protein kinase family and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart.ERK3 is a serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 2 to 3 substrates each. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.

P38 Gamma / MAPK12 References

  • Stiffler MA. et al., 2006, J Am Chem Soc. 128 (17): 5913-22.
  • Joneson T. et al., 1997, J Mol Med. 75 (8): 587-93.
  • Hou SW. et al., 2010, Cancer Res. 70 (7): 2901-10.