GRO Beta / CXCL2 (Protein | Antibody | cDNA Clone | ELISA Kit)

All GRO Beta / CXCL2 reagents are produced in house and quality controlled, including 10 GRO Beta / CXCL2 Antibody, 2 GRO Beta / CXCL2 ELISA, 39 GRO Beta / CXCL2 Gene, 4 GRO Beta / CXCL2 Protein, 3 GRO Beta / CXCL2 qPCR. All GRO Beta / CXCL2 reagents are ready to use.

GRO Beta / CXCL2 Protein (4)

    GRO Beta / CXCL2 Antibody (10)

      GRO Beta / CXCL2 ELISA Kit & Match Antibody ELISA Pair Set (2)

      GRO Beta / CXCL2 cDNA Clone (39)

      NM_002089.3
      NM_009140.2
      NM_053647.1

      GRO Beta / CXCL2 Background

      Chemokine (C-X-C motif) ligand 2 (CXCL2), also called macrophage inflammatory protein 2 (MIP-2), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2), is a small cytokine belonging to the CXC chemokine family. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for CXCL2/MIP-2 or in the presence of a blocking Ab to CXCL2/MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for MIP-2 (as in CXCR2-deficient mice) or in the presence of a blocking Ab to MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. Understanding the regulation of lymphocyte traffic during tolerance induction may lead to novel therapies for autoimmunity, graft acceptance, and tumor rejection. Several studies have implicated the CXCL2 chemokine as a mediator in the development of sepsis. CXCL2/MIP-2 also plays a major role in mediating the neutrophilic inflammatory response of the rodent lung to particles such as quartz, crocidolite asbestos, as well as high doses of other relative innocuous dusts such as titanium dioxide.

      GRO Beta / CXCL2 References

      • Driscoll KE. (2000) TNFalpha and MIP-2: role in particle-induced inflammation and regulation by oxidative stress. Toxicol Lett. 112-113: 177-83.
      • Walpen S, et al. (2001) Nitric oxide induces MIP-2 transcription in rat renal mesangial cells and in a rat model of glomerulonephritis. FASEB J. 15(3): 571-3.
      • Fahey TJ, et al. (1990) Cytokine production in a model of wound healing: the appearance of MIP-1, MIP-2, cachectin/TNF and IL-1. Cytokine. 2(2): 92-9.