CREB3L1 (Protein | Antibody | cDNA Clone | ELISA Kit)

All CREB3L1 reagents are produced in house and quality controlled, including 2 CREB3L1 Antibody, 1 CREB3L1 Gene, 1 CREB3L1 Lysate, 1 CREB3L1 Protein. All CREB3L1 reagents are ready to use.

CREB3L1 Background

CREB3L1, also known as OASIS, is a cellular transcription factor synthesized as a membrane-bound precursor. It is a putative endoplasmic reticulum (ER) stress sensor in astrocytes with a mechanism of activation. OASIS mRNA expression was detected in pancreatic β-cell lines and rodent islets, and the expression level was up-regulated by ER stress-inducing compounds. CREB3L1 may have a role in pancreas development. CREB3L1 may also play an important role in limiting virus spread by inhibiting proliferation of virus-infected cells. In vitro, CREB3L1 binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE. It may play a role in gliosis.

CREB3L1 References

  • Denard B. et al., 2011, Cell Host Microbe. 10 (1): 65-74.
  • Debelenko LV. et al., 2011, 50 (12): 1054-62.
  • Vellanki. et al., 2010, Endocrinology. 151 (9): 4146.