Chitinase-3-like 1 / CHI3L1 (Protein | Antibody | cDNA Clone | ELISA Kit)

All Chitinase-3-like 1 / CHI3L1 reagents are produced in house and quality controlled, including 5 Chitinase-3-like 1 / CHI3L1 Antibody, 26 Chitinase-3-like 1 / CHI3L1 Gene, 2 Chitinase-3-like 1 / CHI3L1 Lysate, 2 Chitinase-3-like 1 / CHI3L1 Protein, 2 Chitinase-3-like 1 / CHI3L1 qPCR. All Chitinase-3-like 1 / CHI3L1 reagents are ready to use.

Chitinase-3-like 1 / CHI3L1 Related Research Area

Chitinase-3-like 1 / CHI3L1 Background

Chitinase-3-like protein 1 (CHI3L1) is a secreted heparin-binding glycoprotein whose expression is associated with vascular smooth muscle cell migration. CHI3L1 is expressed at high levels in postconfluent nodular VSMC cultures and at low levels in subconfluent proliferating cultures. CHI3L1 is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18. In contrast to many other monocyto / macrophage markers, its expression is absent in monocytes and strong induced during late stages of human macrophage differentiation. Elevated levels of CHI3L1 are associated with disorders exhibiting increased connective tissue turnover, such as rheum atoid, arthritis, osteoarthritis, scleroderma, and cirrhosis of liver, but is produced in cartilage from old donors or patiens with osteoarthritis. CHI3L1 is abnormally expressed in the hippocampus of subjects with schizophrenia and may be involved in the cellular response to various environmental events that are reported to increase the risk of schizophrenia.

Chitinase-3-like 1 / CHI3L1 References

  • Zhao XZH, et al. (2007) Functional Variants in the Promoter Region of Chitinase 3-Like 1 (CHI3L1) and Susceptibility to Schizophrenia.The American Journal of Human Genetics. 80 (1): 12-18.
  • Rehli M, et al. (2003) Transcriptional Regulation of CHI3L1, a Marker Gene for Late Stages of Macrophage Differentiation . The Journal of Biological Chemistry. 278: 44058-67.
  • Nishikawa KC, et al. (2003) gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells. Experimental Cell Research. 287 (1): 79-87