ABI2: ABI2 Protein | ABI2 Antibody

ABI2 Background

Abl-interactor 2 (Abi2) is known as a tumor suppressor and a cell migration inhibitor. Abelson (Abl) interactor 2 (Abi-2) has been considered as a key regulator of cell/tissue structural organization and is differentially expressed in leiomyomas,which had been proved a key regulatory function in leiomyomas cellular/tissue structural organization during growth and regression.

Reference for ABI2

  • Kano S, et al. (2008) Tripartite motif protein 32 facilitates cell growth and migration via degradation of abl-interactor 2. Cancer Res 68(14), 5572-5580.
  • Luo X, et al. (2006) The expression of abl interactor 2 in leiomyoma and myometrium and regulation by gnrh analogue and transforming growth factor-beta. Hum Reprod 21(6), 1380-1386.

ABI2 Protein

ABI2 protein function

May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}.

ABI2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

ABI2 Antibody

There are 2 ABI2 antibodies which are validated in multiple tissues with various applications, including IHC-P, ICC/IF, IF. There are 2 ABI2 antibody for IHC-P, 1 ABI2 antibody for ICC/IF, 1 ABI2 antibody for IF. Among all these ABI2 antibodies, there are 2 anti-ABI2 rabbit polyclonal antibodies . All the ABI2 anbodies are produced in house and all are in stock. ABI2 antibody customerized service is available.

ABI2 Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]