Sino Biological - Official Website

Sino Biological and Nanommune (Irvine, California) jointly developed the coronavirus antigen array, Sinommune^TM. This array simultaneously probes 66 antigens from all seven known coronaviruses, along with several types of adenovirus, RSV, MPV, parainfluenza and Influenza viruses.

Sino Biological has released the world-first ELISA kits for the detection of SARS-CoV-2 N and S proteins. These kits employ a standard sandwich ELISA format, allowing rapid quantification of the N and S antigens.

Up to 15th, May, there are 69 publications that have cited SARS-CoV-2 reagents or services providing by Sino Biological Inc. Here we list part of those publications.

• Wang, C et al., A human monoclonal antibody blocking SARS-CoV-2 infection. Nature Communications.2020

• Ou, X et al., Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nature Communications.2020

• Renhong Yan et al., Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2. Science.2020

• Linlin Bao et al., The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice.Nature.2020

• Lamers, MM et al., SARS-CoV-2 productively infects human gut enterocytes. Science.2020

• Rockx, B et al., Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model. Science.2020

• Long, QX et al., Antibody responses to SARS-CoV-2 in patients with COVID-19. Nature Medicine.2020

• Ni, L et al., Detection of SARS-CoV-2-specific humoral and cellular immunity in COVID-19 convalescent individuals. Immunity.2020

• Huibin Lv, et al., Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections. Cell Reports.2020

• Yunlong Cao, et al., Potent neutralizing antibodies against SARS-CoV-2 identified by high-throughput single-cell sequencing of convalescent patients’ B cells.Cell.2020

• Dora Pinto, et al., Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody.Nature.2020

• Sino Biological is the first company worldwide to offer recombinant proteins of SARS-CoV-2. Learn more>>

• Sino Biological Inc. has received support from the Bill & Melinda Gates foundation for the colloidal gold and ELISA based diagnosis of COVID-19. Learn more>>

• Sino Biological Inc. will launch the world largest recombinant viral antigen collection, ProVir^TM, on April 1st. Learn more>>

• Sino Biological Partners with Nanommune Inc. to Develop and Market a Novel Coronavirus Multiplex Serological Assay, Sinommune^TM. Learn more>>

• GeoVax and Sino Biological Establish Exclusive Supply Agreement for Research Grade Bioreagents Related to SARS-CoV-2 (COVID-19) Vaccine Development. Learn more>>

Research and Develop Proteins for Almost 50 Immune Checkpoints Targets

Covering Multiple Species and Various Tags

Binding Activity is Assayed and Confirmed

Covering Drug Development Target, CAR-T Target, Fc Receptors, Immune Checkpoint, etc.

Binding Activity to MAb Drugs Validated; Cell-based Activity Assay

Multiple Species, Various Tags

Strict Quality Control to Guarantee Activity on Every Recombinant Biotinylated Protein

Cover Almost All MAb Drug Target Proteins: B7/CD28, PCSK9, TNFSFs…

Biotinylated CAR-T Relevant Proteins & Fc Receptor Proteins

Biotinylated Fc Receptor Protein Available

High Purity: >95%; Low Endotoxin: <1.0 EU/μg

Multiple Species: Human, Mouse, Rat, Monkey

More than 60 Subtypes: H1-H18, N1-N11, Influenza B

More than 250 Strains: Vaccine Strains, HPAI Strains, High Attention Strains, New Strains

HA: High Hemagglutination Activity; NA: High Eenzymatic Activity

Covering All Cytokine Families (900 Cytokines & Receptors), Multiple Species, Various Tags

GMP Level Cytokines Available; Apply to Cell Culture,

Animal Free, Carrier Free, High Purity; Better Bioactivity

80% Using Eukaryotic Recombinant Proteins as Immunogens

More Sensitive and Specific, Better for Small Molecules

10-100× Higher Affinity than Mouse Antibodies

Examinations by Multiple Tissues;Specificity Ensured by Antigen Blocking

Excellent Reproducibility, High Sensitivity

Strict Quality Assurance System

High Sensitivity: Detects Lower Expression Levels

Different Positions: Recognizes His Tags at N-terminal, C-terminal or Internal

Broad Spectrum: Identify More His-tagged Proteins

8 International QC Test Indicators

ELISA Kit for Human Cytokines: IL-4,IL-6,IL-10,IL-12,IL-17A,GM-CSF,TNFα,TNFβ, CXCL9…

Bright Fluorescence, High pH-stability

Full-length Sequence Confirmed, Expression Validated

Recommended for Gene Expression Analysis, Cell Labeling and Organelle Labeling

Higher Transfection Efficiency

Inorganic Reagent without Animal Ingredients

Higher Protein Expression, Lower Cytotoxicity

For DNA Transfection, Eukaryotic Cells Like HEK293

For Both Adherent and Suspension Cells

Be Used in More than 1000 Protein's Purification, High Protease Activity

Suitable for Recombinant Protein's Purification

Be Used in More than 2000 Proteins' Purification

Without Tag, Easy to be Removed

Suitable for Vaccine's Purification, Recombinant Antibody's Purification

Suitable for Sample Preparation of WB and The Like

>6000 Proteins Expression and Purification Experience

Multiple Protein Expression Systems; Optimized High-efficiency Expression Vectors

Proprietary Medium Formulation; High Cell Density Culturing

Unmatched speed: >100Mab Production in 2 Weeks

Superior Quality: Proprietary Technology and Optimized Process

Highly Flexible: Multiple Production Scales and Quality Standards

Optimized Immunization; High Effcienct Electrofusion

Phage Display Library Technology; Solid/Liquid-phage Screening

Hybridoma Serum-free Cell Culture; Multiple Purification Methods

Varied Antigens: Recombinant Protein, Natural Protein, Peptide, Cell, DNA

A Full Set of Preclinical Research Experience for Multiple Key Drug Targets

Established Cell Activity Evaluation Models for Many Antibodies Against Key Drug Targets (PD-1, PD-L1, and EGFR, etc)

Successfully Screened Dozens of Candidate Antibodies with Good Biological Activity and Druggability Against Several Important Drug Targets