uracil-DNA glycosylase Protein

uracil-DNA glycosylase Products

uracil-DNA glycosylase Protein, Recombinant

Molecule	Species	Description	Cat. No
uracil-DNA glycosylase	Human	Uracil-DNA glycosylase Protein, Recombinant, with GST Tag	12939-H09E

uracil-DNA glycosylase Related Areas

Enzyme>>Other>>uracil-DNA glycosylase

uracil-DNA glycosylase Alternative Names

uracil-DNA glycosylase, UNG, DGU, DKFZp781L1143, HIGM4, UDG, UNG1, UNG15, UNG2 [Homo sapiens]

uracil-DNA glycosylase, Ung, UNG1, UNG2 [Mus musculus]

uracil-DNA glycosylase Background

Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells. Uracil-DNA glycosylase exists in two forms: mitochondrial uracil-DNA glycosylase 1 (UNG1) and nuclear uracil-DNA glycosylase 2 (UNG2). uracil-DNA glycosylase. This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. Defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 (HIGM5). A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.

uracil-DNA glycosylase Related Studies

1. Akbari M, et al. (2007) Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress. Neuroscience. 145(4):1201-12.
2. Slupphaug G, et al. (1996) Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase. Biochemistry. 34(1): 128-38.
3. Pytel D, et al. (2008) Uracil-DNA glycosylases. Postepy Biochem. 54(4): 362-70.