uPAR / PLAUR Protein

uPAR / PLAUR Protein Overview

uPAR / PLAUR reagents

The urokinase-type plasminogen activator receptor is a key molecule in the regulation of cell surface plasminogen activation and, as such, plays an important role in many normal as well as pathologic processes (summary by Huai et al., 2006).

uPAR / PLAUR protein name

Recommended name
Urokinase plasminogen activator surface receptor
Short name
U-PAR||uPAR
Aliases
CD87, UPAR, URKR, urokinase plasminogen activator surface receptor, urokinase-type plasminogen activator (uPA) receptor
Alternative name
Monocyte activation antigen Mo3 CD_antigen: CD87

uPAR / PLAUR Protein Sequence

Species Human uPAR / PLAUR protein
Length 335
Mass (Da) 36978
Sequence Human uPAR / PLAUR protein sequence
Species Mouse uPAR / PLAUR protein
Length 327
Mass (Da) 35428
Sequence Mouse uPAR / PLAUR protein sequence
Species Rat uPAR / PLAUR protein
Length 328
Mass (Da) 35753
Sequence Rat uPAR / PLAUR protein sequence

uPAR / PLAUR Protein Molecular Weight & PI

Urokinase plasminogen activator surface receptor precursor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD87 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 23-305 Urokinase plasminogen activator surface

Molecular weight (Da)

31460.23

Theoretical pI

5.95

uPAR / PLAUR Protein Structure

crystal structure of urokinase plasminogen activator receptor
Deposited
2005-02-18   Released:  2005-05-10
Deposition Author(s)
Llinas, P., Le Du, M.H., Gardsvoll, H., Dano, K., Ploug, M., Gilquin, B., Stura, E.A., Menez, A.
Organism(s)
Homo sapiens
Expression System
Drosophila melanogaster
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.7000 Å
R-Value Free
0.315
R-Value Work
0.245
1YWH From PDB

Human uPAR / PLAUR protein Secondary structure

uPAR / PLAUR Protein Interaction

Recombinant uPAR / PLAUR Protein Feature

uPAR / PLAUR Protein, Mouse, Recombinant (His & Fc Tag)

High Purity
> 97 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measured by its binding ability in a functional ELISA . Immobilized human uPA at 5 μg/ml (100 μl/well) can bind mouse PLAUR with a linear ranger of 1.6-40 ng/ml .

Recombinant uPAR / PLAUR protein citations

Title
A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease
Year
2014
Author
Spinale, JM;Mariani, LH;Kapoor, S;Zhang, J;Weyant, R;Song, PX;Wong, HN;Troost, JP;Gadegbeku, CA;Gipson, DS;Kretzler, M;Nihalani, D;Holzman, LB;
Journal
Kidney Int.
Title
A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease
Year
2014
Author
Spinale, JM;Mariani, LH;Kapoor, S;Zhang, J;Weyant, R;Song, PX;Wong, HN;Troost, JP;Gadegbeku, CA;Gipson, DS;Kretzler, M;Nihalani, D;Holzman, LB;
Journal
Kidney Int.
Title
Improved positron emission tomography imaging of glioblastoma cancer using novel (68)Ga-labeled peptides targeting the urokinase-type plasminogen activator receptor (uPAR)
Year
2017
Author
Loft, MD;Sun, Y;Liu, C;Christensen, C;Huang, D;Kjaer, A;Cheng, Z;
Journal
Amino Acids

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