TROP2 Protein

TROP2 Protein Overview

TROP2 protein family

Belongs to the EPCAM family.

TROP2 protein name

Recommended name
Tumor-associated calcium signal transducer 2
Aliases
EGP-1, GA733-1, TROP2
Alternative name
Cell surface glycoprotein Trop-2 Membrane component chromosome 1 surface marker 1 Pancreatic carcinoma marker protein GA733-1

TROP2 Protein Sequence

Species Human TROP2 protein
Length 323
Mass (Da) 35709
Sequence Human TROP2 protein sequence
Species Mouse TROP2 protein
Length 317
Mass (Da) 35574
Sequence Mouse TROP2 protein sequence
Species Rat TROP2 protein
Length 317
Mass (Da) 35514
Sequence Rat TROP2 protein sequence

TROP2 Protein Molecular Weight & PI

Tumor-associated calcium signal transducer 2 precursor (Cell surface glycoprotein Trop-2) (Membrane component chromosome 1 surface marker 1) (Pancreatic carcinoma marker protein GA733-1) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 27-323 Tumor-associated calcium signal

Molecular weight (Da)

33120.13

Theoretical pI

8.98

TROP2 Protein Structure

Transmembrane-cytosolic part of Trop2 explored by NMR and Molecular Dynamics
Deposited
2013-07-08   Released:  2014-07-09
Deposition Author(s)
Vidmar, T., Pavi, M., Ilc, G., Plavec, J., Lenari, B.
Organism(s)
Homo sapiens
Experimental Data Snapshot
Method
SOLUTION NMR
2MAE From PDB

Human TROP2 protein Secondary structure

TROP2 Protein Interaction

Recombinant TROP2 Protein Feature

TROP2 Protein, Mouse, Recombinant (Fc Tag)

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. When 5 x 10E4 cells/well are added to coated plates (40 μg/mL, 100 μL/well), > 50% cells will adhere after 1 hour at 37℃.

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