CD antigens which indicates a defined subset of cellular surface receptors (epitopes) that identify cell type and stage of differentiation, and which are recognized by antibodies.There are more than 250 identified clusters, each a different molecule, coating the surface of B lymphocytes and T lymphocytes. T cells mature in the thymus and developed from hematopoietic stem cells in the bone marrow. There are several types of T cells based on their specific function: helper/effector, cytotoxic, memory, regulatory and gamma delta (γδ) T cells. Sino Biological Inc offers a range of products to facilitate the study of many T cell actions, including migration, adhesion, antigen recognition, activation and proliferation.
CD4 is an membrane glycoprotein expressed predominantly on T cell , providing the surface protein to which HIV attaches itself in order to invade the cell. CD4 is also found on the surface of monocytes, macrophages, dendritic cells, astrocytes, keratinocytes and glial cells. The number of serum T4 cells is employed to measure the health of the immune system in people infected with HIV.
CD8 is a co-receptor for the T cell receptor (TCR).CD8 is also be found on natural killer cells, cortical thymocytes, and dendritic cells.