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SPAG9  Protein, Antibody, ELISA Kit, cDNA Clone

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SPAG9 Related Pathways

    SPAG9 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    SPAG9 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    SPAG9 Summary & Protein Information

    SPAG9 Background

    Subunit structure: Homodimer. The homodimer interacts with ARF6, forming a heterotetramer. Homooligomer. Interacts with MAX, MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8. Interacts with NFKB1. {ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:15693750, ECO:0000269|PubMed:19644450}.
    Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Note=Perinuclear distribution in response to stress signals such as UV radiation.; Isoform 5: Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.
    Tissue specificity: Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients. {ECO:0000269|PubMed:14662895, ECO:0000269|PubMed:16112646, ECO:0000269|PubMed:9480848}.
    Induction: Isoform 3 is increased in systemic sclerosis fibroblasts. {ECO:0000269|PubMed:14662895}.
    Post-translational: Phosphorylated by MAPK8 and MAPK14. {ECO:0000250}.
    Sequence similarity: Belongs to the JIP scaffold family. {ECO:0000305}.
    General information above from UniProt

    SPAG9 Alternative Name

    JLP,CT89,HLC4,HLC6,JIP4,PHET,HLC-6,JIP-4,PIG6, [homo-sapiens]
    JLP,Jip4,syd1,JSAP2,JSAP2a,AW552012,Mapk8ip4,3110018C07Rik,4733401I23Rik,4831406C20Rik, [mus-musculus]

    SPAG9 Related Studies

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