CXCR4/CD184 cDNA Clone: Expression and Clone Vector / Plasmid

CXCR4/CD184 cDNA / Gene Overview

CXCR4 cDNA / gene is a gene with protein product which located on 2q22.1. The CXCR4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 231 organisms have orthologs with human gene CXCR4.

CXCR4/CD184 cDNA / Gene Function

This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

CXCR4/CD184 cDNA / Gene Sequence

LOCUS
AF005058 5161 bp DNA linear PRI 21-SEP-2000
DEFINITION
Homo sapiens chemokine receptor (CXCR-4) gene, complete cds.
ACCESSION
AF005058
VERSION
AF005058.1

This sequence information is just for reference only.

CXCR4/CD184 Family & Reagents

Gene family

CXCR4/CD184 Gene family reagents (CD molecules)

Approved Symbol Reagent list
MELTF
B3gat1
IL17RA
CD2
CD82
FCGR3A
HAVCR1
PDCD1LG2
IL21R
LAMP1
Approved Symbol Reagent list
IL18R1
IL1R1
ENPEP
ADGRE5
PROM1
CSF2RB
CD63
CD1B
ICAM2
LILRB5

CXCR4/CD184 cDNA / Gene Alias

  • CD184
  • D2S201E
  • fusin
  • HM89
  • HSY3RR
  • LESTR
  • NPY3R
  • NPYR
  • NPYY3R

CXCR4/CD184 cDNA / Gene Expression

Biased expression in bone marrow (RPKM 479.2), lymph node (RPKM 201.0) and 9 other tissues