CD74 Protein

CD74 Protein Overview

CD74 reagents

In the synthesis of class II antigens of the major histocompatibility complex, newly synthesized alpha and beta chains form complexes with gamma chains in the endoplasmic reticulum. After transport of the complex to the Golgi apparatus, and concomitant with terminal glycosylation, the gamma chain dissociates from the other 2 chains. Subsequently, at least some of the gamma chains become integrated into the plasma membrane in a transmembrane position. Claesson et al. (1983) isolated a cDNA encoding the human gamma chain from a Raji lymphoblastoid cell cDNA library. The deduced 216-amino acid protein contains a short N-terminal cytoplasmic segment, followed by a transmembrane region and an extracellular C-terminal segment. It lacks an N-terminal signal sequence. In vitro-translated human gamma chain had an apparent molecular mass of 33 kD by SDS-PAGE. Schori et al. (2007) stated that mouse Cd74 is a nonpolymorphic type II integral membrane protein with an N-terminal 28-amino acid cytoplasmic tail, a 24-amino acid transmembrane region, and a 150-amino acid luminal domain. Differential splicing results in 31- and 41-kD isoforms designated p31 and p41, respectively.

CD74 protein name

Recommended name
HLA class II histocompatibility antigen gamma chain
gamma chain of class II antigens, HLA-DR-gamma, Ia-associated invariant chain, MHC HLA-DR gamma chain
Alternative name
HLA-DR antigens-associated invariant chain Ia antigen-associated invariant chain Ii p33 CD antigen CD74

CD74 Protein Sequence

Species Human CD74 protein
Length 296
Mass (Da) 33516
Sequence Human CD74 protein sequence
Species Mouse CD74 protein
Length 279
Mass (Da) 31557
Sequence Mouse CD74 protein sequence
Species Rat CD74 protein
Length 280
Mass (Da) 31642
Sequence Rat CD74 protein sequence

CD74 Protein Molecular Weight & PI

HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (p33) (CD74 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-296 HLA class II histocompatibility antigen

Molecular weight (Da)


Theoretical pI


CD74 Protein Structure

1999-02-02   Released:  1999-02-16
Deposition Author(s)
Jasanoff, A., Wagner, G., Wiley, D.C.
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot

Human CD74 protein Secondary structure

CD74 Protein Interaction

Recombinant CD74 Protein Feature

CD74 Protein, Human, Recombinant (His Tag)

High Purity
> 80 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measured by its binding ability in a functional ELISA . Immobilized human CD74 at 5 μg/ml (100 μl/well) can bind biotinylated human CTSL1 with a linear range of 3.2-400 ng/ml .

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