IFNA14 Protein, Mouse, Recombinant (Fc Tag)

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IFNA14 Protein, Mouse, Recombinant (Fc Tag): Product Information

Purity
> 92 % as determined by SDS-PAGE
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Activity
Measured in antiviral assay using L929 cells infected with vesicular stomatitisvirus (VSV).
The ED50 for this effect is typically 10-100 pg/mL.
Protein Construction
A DNA sequence encoding the secreted form of mouse IFNA14 (NP_996858.1) (Cys 24-Lys 189) was fused with the Fc region of human IgG1 at the N-terminus.
Accession#
Expressed Host
HEK293 Cells
Species
Mouse
Predicted N Terminal
Glu
Molecule Mass
The recombinant mouse IFNA14/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 426 amino acids and has a predicted molecular mass of 47.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm IFNA14/Fc monomer is approximately 50 kDa.
Formulation
Lyophilized from sterile PBS, pH 7.4
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IFNA14 Protein, Mouse, Recombinant (Fc Tag): Images

Measured in antiviral assay using L929 cells infected with vesicular stomatitisvirus (VSV). The ED50 for this effect is typically 10-100 pg/mL.

IFNA14 Protein, Mouse, Recombinant (Fc Tag): Alternative Names

OTTMUSG00000007662 Protein, Mouse

IFNA14 Background Information

Full Name
interferon, alpha 14
References
  • Lau JY, et al. (1993) Discrepancy between biochemical and virological responses to interferon-alpha in chronic hepatitis C. Lancet. 342(8881): 1208-9.
  • Kessler DS, et al. (1990) Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator. Genes Dev. 4(10): 1753-65.
  • Gutterman JU. Cytokine therapeutics: lessons from interferon alpha. Proc Natl Acad Sci U S A. 91(4): 1198-205.
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