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Receptor Protein

Receptor Proteins as drug targets

 

Receptor binds to cytokine & growth factor

Cytokine Receptors   Growth Factor Receptors
 

Receptor Proteins by Differentiation Cells

Part of Featured Receptor Proteins

Catalogue Product name Purity Endotoxin
10001-H08B Human EGFR / HER1 / ErbB1 Protein (His Tag) > 95 % as determined by SDS-PAGE < 1.0 EU/μg protein
10004-H08H Human HER2 / ErbB2 Protein (His Tag) > 90 % as determined by SDS-PAGE < 1.0 EU/μg protein
13482-H08H Human B7-H5 / Gi24 / VISTA Protein (His Tag) > 95 % as determined by SDS-PAGE < 1.0 EU/μg protein
51091-M02H Mouse EGFR / HER1 / ErbB1 Protein (Fc Tag) > 90 % as determined by SDS-PAGE < 1.0 EU/μg protein
50324-M03H Mouse CD40 / TNFRSF5 Protein (His & Fc Tag) > 90 % as determined by SDS-PAGE < 1.0 EU/μg protein
50613-M08H Mouse ACVR2A / ActrIIa Protein (His Tag) > 97 % as determined by SDS-PAGE < 1.0 EU/μg protein
80018-R08H Rat CD32b / FCGR2B Protein (His Tag) > 97 % as determined by SDS-PAGE < 1.0 EU/μg protein
81072-R02H Rat IL-6R / CD126 Protein (Fc Tag, ECD) > 90 % as determined by SDS-PAGE < 1.0 EU/μg protein
90295-C08H Cynomolgus HER2 / ErbB2 Protein (His Tag) > 90 % as determined by SDS-PAGE < 1.0 EU/μg protein
80101-R08H Rat VEGFR1 / FLT-1 Protein (His Tag) > 90 % as determined by SDS-PAGE < 1.0 EU/μg protein
90014-C08H Cynomolgus CD32b / FCGR2B Protein (His Tag) > 95 % as determined by SDS-PAGE < 1.0 EU/μg protein
90304-CCCH Cynomolgus / Rhesus c-MET / HGFR Protein > 90 % as determined by SDS-PAGE < 1.0 EU/μg protein

Receptor Protein by Species

Receptors Related Products in Sino Biological Inc.

Receptor Proteins background

Receptor proteins are located within the cell surface membrane, nucleus membrane or other cellular organelle membrane. They can bind to corresponding ligands to initiate cellular signaling pathways. For cell surface receptors, such as receptor tyrosine kinases, interleukin receptors and receptors of growth factors, they are usually subdivided into three domains, extracellular domain, transmembrane domain and intracellular domain. Receptor proteins form the largest family of biological targets. For example, GPCR (G protein coupled receptor) is the target of more than 50% of current drugs. GPCR family members share a unique structure with seven-transmembrane domains. Receptor tyrosine kinases are single transmembrane proteins. They are key regulators for normal cellular processes and also involved in developing many types of cancer. The extracellular part of receptor tyrosine kinases is responsible for binding to growth factors and cytokines. The intracellular domain has kinase activity. Many studies have focused on development therapeutic drugs to both extracellular and intracellular domains of receptor tyrosine kinases.

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