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RAB1A  Protein, Antibody, ELISA Kit, cDNA Clone

RAB1A Related Area

RAB1A Related Pathways

RAB1A Related Protein, Antibody, cDNA Gene, and ELISA Kits

RAB1A Related Protein, Antibody, cDNA Gene, and ELISA Kits

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RAB1A Summary & Protein Information

RAB1A Background

Subunit structure: May interact with YIPF5. Interacts with C9orf72 (By similarity). Interacts with GDI1; this promotes dissociation from membranes. Interacts with L.pneumophila AnkX, LidA and Lem3. Interacts with L.pneumophila and L.drancourtii LepB; this enhances RAB1A GTPase activity. Interacts with L.pneumophila DrrA; this disrupts the interaction between RAB1A and GDI1 and promotes the exchange of RAB1A-bound GDP with GTP. Interacts with E.coli EspG and S.flexneri VirA; this impairs ER to Golgi trafficking and protein secretion. Identified in a complex composed of RAB1A, ARF6 and E.coli EspG. {ECO:0000250, ECO:0000269|PubMed:19942850, ECO:0000269|PubMed:20176951, ECO:0000269|PubMed:21822290, ECO:0000269|PubMed:22158903, ECO:0000269|PubMed:22416225, ECO:0000269|PubMed:22939626, ECO:0000269|PubMed:23588383, ECO:0000269|PubMed:23815289, ECO:0000269|PubMed:23821544, ECO:0000269|Ref.22}.
Subcellular location: Golgi apparatus. Endoplasmic reticulum. Early endosome. Cytoplasm, cytosol. Membrane. Melanosome {ECO:0000250}. Note=Alternates between membrane-associated and cytosolic forms.
Post-translational: Phosphorylated by CDK1 kinase during mitosis. {ECO:0000269|PubMed:1902553, ECO:0000269|PubMed:21822290, ECO:0000269|PubMed:22158903}.; Phosphocholinated at Ser-79 by L.pneumophila AnkX, leading to displace GDP dissociation inhibitors (GDI). Both GDP-bound and GTP-bound forms can be phosphocholinated. Dephosphocholinated by L.pneumophila Lem3, restoring accessibility to L.pneumophila GTPase effector LepB.
Sequence similarity: Belongs to the small GTPase superfamily. Rab family. {ECO:0000305}.
General information above from UniProt

RAB1A Alternative Name

RAB1A Related Studies

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