R-Cadherin / CDH4 (Protein | Antibody | cDNA Clone | ELISA Kit)

All R-Cadherin / CDH4 reagents are produced in house and quality controlled, including 3 R-Cadherin / CDH4 Antibody, 14 R-Cadherin / CDH4 Gene, 1 R-Cadherin / CDH4 Lysate, 1 R-Cadherin / CDH4 Protein. All R-Cadherin / CDH4 reagents are ready to use.

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R-Cadherin / CDH4 Related Research Area

R-Cadherin / CDH4 Background

The cadherin superfamily is a large family that engage in both homo- and heterotypic, calcium-dependent, cell-cell adhesion events, and can be divided into at least four subfamilies based on the extracellular (EC) regions and cytoplasmic domains, that is: classical cadherins, desmosomal cadherins, protocadherins, and cadherin-like molecules. Human cadherin 4, type 1, R-cadherin (retinal), also known as CDH4, CAD4 and RCAD, is a classical cadherin from the cadherin superfamily. It is a calcium-dependent adhesion molecule and a type I transmembrane glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. CDH4 is thought to play an important role during brain segmentation and neuronal outgrowth, and also exerts critical actions in kidney and muscle development. CDH4 is expressed in vascular smooth muscle, pancreatic β-cells, thyroid follicular cells, sensory neurons of the dorsal root ganglia, and, possibly, astrocytes and endothelium of the retina. As a classic cadherin, CDH4 forms both homodimers and heterodimers with N-cadherin. The extracellular region of human CDH4 is 96% aa identical to that of mouse CDH4.

R-Cadherin / CDH4 References

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  • Matsunami, H. et al., 1993, J. Cell Sci. 106: 401-409.
  • Tanihara, H. et al.,1995, Cell Adhes. Commun. 2 (1): 15-26.
  • Shan, W-S., et al., 2000, J. Cell Biol. 148: 579-590.
  • Fagman, H. et al, 2003, Endocrinology. 144: 3618-3624.
  • Koch, A.W. et al., 2004, Cell. Mol. Life Sci. 61: 1884-1895.