uPAR / PLAUR: uPAR / PLAUR Protein | uPAR / PLAUR Antibody

uPAR / PLAUR Gene family

uPAR / PLAUR Background

Urokinase plasminogen activator (uPA) and/or its receptor (uPAR) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumours. uPAR and uPA levels in both resected tumor tissue and plasma are of independent prognostic significance for patient survival in several types of human cancer. This system has classically been thought to drive tumor progression by mediating directed extracellular proteolysis on the surface of migrating or invading cells, and intervening with this proteolysis by targeting uPAR has been proposed to represent a novel approach for inhibiting tumor progression. uPAR, also known as PLAUR or CD87, has been implicated in the growth, metastasis, and angiogenesis of several solid and hemotologic malignancies. uPAR is a highly glycosylated, 55-6kDa integral membrane protein linked to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. It is part of a cell surface system that also consists of the serine protease uPA and several specific inhibitors (plasminogen activator inhibitors 1 and 2). Additionally, the analysis of CD87 (urokinase-type plasminogen activator receptor - uPAR) expression has a potential role in the diagnostic or prognostic work-up of several hematological malignancies, particularly acute leukemia and multiple myeloma.

Reference for uPAR / PLAUR

  • Romer J, et al. (2004) The urokinase receptor as a potential target in cancer therapy. Curr Pharm Des. 10(19): 2359-76.
  • Bn MC, et al. (2004) CD87 (urokinase-type plasminogen activator receptor), function and pathology in hematological disorders: a review. Leukemia. 18(3): 394-400.
  • Pillay V, et al. (2007) The urokinase plasminogen activator receptor as a gene therapy target for cancer. Trends Biotechnol. 25(1): 33-9.
  • Mazar AP. (2008) Urokinase plasminogen activator receptor choreographs multiple ligand interactions: implications for tumor progression and therapy. Clin Cancer Res. 14(18): 5649-55.

uPAR / PLAUR Protein

uPAR / PLAUR protein function

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

uPAR / PLAUR protein expression

Tissue specificity

Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.

uPAR / PLAUR protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    335.00
  • Mass (Da)
    36.00

uPAR / PLAUR Antibody

There are 18 uPAR / PLAUR antibodies which are validated in multiple tissues with various applications, including IHC-P, ELISA(Cap), ELISA(Det), FCM, ELISA, ICC/IF, IP. There are 2 uPAR / PLAUR antibody for IHC-P, 1 uPAR / PLAUR antibody for ELISA(Cap), 1 uPAR / PLAUR antibody for ELISA(Det), 8 uPAR / PLAUR antibody for FCM, 7 uPAR / PLAUR antibody for ELISA, 1 uPAR / PLAUR antibody for ICC/IF, 1 uPAR / PLAUR antibody for IP. Among all these uPAR / PLAUR antibodies, there are 5 anti-uPAR / PLAUR rabbit polyclonal antibodies , 11 anti-uPAR / PLAUR mouse monoclonal antibodies , 2 anti-uPAR / PLAUR rabbit monoclonal antibodies . All the uPAR / PLAUR anbodies are produced in house and all are in stock. uPAR / PLAUR antibody customerized service is available.

uPAR / PLAUR Gene

PLAUR gene / cDNA is a protein-coding gene which located on 19q13. The PLAUR gene is conserved in chimpanzee, dog, cow, mouse, and rat.129 organisms have orthologs with human gene PLAUR.