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PIK3R2  Protein, Antibody, ELISA Kit, cDNA Clone

PIK3R2 Related Area

PIK3R2 Related Protein, Antibody, cDNA Gene, and ELISA Kits

PIK3R2 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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PIK3R2 Summary & Protein Information

PIK3R2 Background

Subunit structure: Heterodimer of a regulatory subunit PIK3R2 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD) (PubMed:23604317). Interacts with AXL (PubMed:9178760). Interacts with FLT1 (tyrosine-phosphorylated) and FLT4 (tyrosine-phosphorylated) (PubMed:9600074, PubMed:15102829). Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Interacts with FBXL2; PIK3R2 is a substrate of the SCF(FBXL2) complex (PubMed:23604317). Interacts with PTPN13; dephosphorylates PIK3R2 (PubMed:23604317). Interacts with XBP1 isoform 2; the interaction is direct and induces translocation of XBP1 isoform 2 into the nucleus in a ER stress-and/or insulin-dependent but PI3K-independent manner (By similarity). Interacts with PIK3R1; the interaction is dissociated in an insulin-dependent manner (By similarity). {ECO:0000250|UniProtKB:O08908, ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:23604317, ECO:0000269|PubMed:9178760, ECO:0000269|PubMed:9600074}.
Domain: The SH2 2 domain is required for interaction with FBXL2 and PTPN13. {ECO:0000269|PubMed:23604317}.
Post-translational: Phosphorylated in response to signaling from activated receptor-type protein kinases (PubMed:19690332, PubMed:20068231). Dephosphorylated by PTPRJ (PubMed:18348712). Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination (PubMed:23604317). {ECO:0000269|PubMed:18348712, ECO:0000269|PubMed:23604317}.; Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2. {ECO:0000303|PubMed:23604317}.
Involvement in disease: DISEASE: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 (MPPH1) [MIM:603387]: A syndrome characterized by megalencephaly, hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome. {ECO:0000269|PubMed:22729224}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Belongs to the PI3K p85 subunit family. {ECO:0000305}.; Contains 1 Rho-GAP domain. {ECO:0000255|PROSITE-ProRule:PRU00172}.; Contains 2 SH2 domains. {ECO:0000255|PROSITE-ProRule:PRU00191}.; Contains 1 SH3 domain. {ECO:0000255|PROSITE-ProRule:PRU00192}.
General information above from UniProt

PIK3R2 Alternative Name

P85B,MPPH1,p85-BETA,MPPH,P85, [homo-sapiens]
p85beta, [mus-musculus]

PIK3R2 Related Studies

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