p53 Protein & Antibody (TP53 Protein)

Tumor protein p53

p53 Products

p53 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
p53/TP53	Cynomolgus	p53/TP53 Protein, Recombinant, Native	90001-CNAE

p53 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Cynomolgus p53/TP53	WB, ELISA	p53 / TP53 Antibody (Antigen Affinity Purified)	90001-RP02
Cynomolgus p53/TP53	WB, ELISA	p53 / TP53 Antibody	90001-MM06

p53 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
p53/TP53	Human	Human p53/TP53 transcript variant 1 cDNA Clone / ORF Clone	HG10182-M
p53/TP53	Mouse	Mouse p53/TP53 cDNA Clone / ORF Clone	MG50534-M
p53/TP53	Cynomolgus	Cynomolgus monkey p53/TP53 cDNA Clone / ORF Clone	CG90001-G

p53 Related Areas

Cancer>>Cancer Biomarkers>>p53/TP53

Signal Transduction>>Transcription Factor & Regulator>>p53/TP53

p53 Alternative Names

p53, TP53, FLJ92943, LFS1, P53, TRP53 [Homo sapiens]

p53, Trp53, RP23-56I20.1, Tp53, bbl, bfy, bhy, p44 [Mus musculus]

p53 Background

p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damage, hypoxia, spindle damage). Activation of p53 begins through a number of mechanisms including phosphorylation by ATM, ATR, Chk1 and MAPKs. MDM2 is a ubiquitn ligase that binds p53 and targets p53 for proteasomal degradation. Phosphorylation, p14ARF and USP7 prevent MDM2-p53 interactions, leading to an increase in stable p53 tetramers in the cytoplasm. Further modifications such as methylation and acetylation lead to an increase in Tp53 binding to gene specific response elements. Tp53 regulates a large number of genes (>100 genes) that control a number of key tumor suppressing functions such as cell cycle arrest, DNA repair, senescence and apoptosis. Whilst the activation of p53 often leads to apoptosis, p53 inactivation facilitates tumor progression. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Defects in TP53 are a cause of esophageal cancer, Li-Fraumeni syndrome, lung cancer and adrenocortical carcinoma.

p53 Related Studies

1. Bakhrat A, et al. (2010) Drosophila Chk2 and p53 proteins induce stage-specific cell death independently during oogenesis. Apoptosis. 15(12):1425-34.
2. Kurzhals RL, et al. (2011) Chk2 and p53 are haploinsufficient with dependent and independent functions to eliminate cells after telomere loss. PLoS Genet. 7(6):e1002103.
3. Pardi N, et al. (2011) In vivo effects of abolishing the single canonical sumoylation site in the C-terminal region of Drosophila p53. Acta Biol Hung. 62(4):397-412.
4. Wells BS, et al. (2012) Maintenance of imaginal disc plasticity and regenerative potential in Drosophila by p53. Dev Biol. 361(2):263-76.