p53 (Protein|Antibody|cDNA Clone|ELISA Kit)

All p53 reagents are produced in house and quality controlled, including 7 p53 Antibody, 1 p53 ELISA, 45 p53 Gene, 1 p53 IPKit, 1 p53 Protein, 2 p53 qPCR. All p53 reagents are ready to use.

Recombinant p53 proteins are expressed by E. coli with fusion tags as Native.

p53antibodies are validated with different applications, which are ELISA, WB, ELISA(Det), IP, ELISA(Cap), IHC-P, ICC/IF, IF.

p53cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each p53 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

p53ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.

p53 Protein (1)


p53 Protein, Cynomolgus, Recombinant


Expression host: E. coli

Cynomolgus p53 Protein 12711

p53 Antibody (7)

Anti-p53 Antibody


Application: WB,ELISA,ELISA(Det)

Clonality: MAb

Cynomolgus p53 Western blot (WB) 13754

Anti-p53 Antibody


Application: WB,ELISA,IP

Clonality: MAb

Cynomolgus p53 Immunoprecipitation(IP) 6225

Anti-p53 Antibody


Application: ELISA(Cap)

Clonality: MAb

Anti-p53 Antibody


Application: IHC-P,ICC/IF,IF

Clonality: MAb

Cynomolgus p53 Immunofluorescence(IF) 3064

Anti-p53 Antibody


Application: ELISA

Clonality: PAb

Anti-p53 Antibody


Application: ELISA

Clonality: PAb

Anti-p53 Antibody


Application: WB

Clonality: PAb

Human p53 Western blot (WB) 13030

p53 ELISA KIT & match antibody elias pair set ( 1 )

p53 Matched ELISA Antibody Pair Set,Cynomolgus


Assay Range: 156.25 pg/ml

Cynomolgus p53 ELISA Pair Set Standard Curve 14019

p53 cDNA Clone (45)


p53 qPCR Primer (2)

p53 IP Kit (1)

p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damage, hypoxia, spindle damage). Activation of p53 begins through a number of mechanisms including phosphorylation by ATM, ATR, Chk1 and MAPKs. MDM2 is a ubiquitn ligase that binds p53 and targets p53 for proteasomal degradation. Phosphorylation, p14ARF and USP7 prevent MDM2-p53 interactions, leading to an increase in stable p53 tetramers in the cytoplasm. Further modifications such as methylation and acetylation lead to an increase in Tp53 binding to gene specific response elements. Tp53 regulates a large number of genes (>100 genes) that control a number of key tumor suppressing functions such as cell cycle arrest, DNA repair, senescence and apoptosis. Whilst the activation of p53 often leads to apoptosis, p53 inactivation facilitates tumor progression. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Defects in TP53 are a cause of esophageal cancer, Li-Fraumeni syndrome, lung cancer and adrenocortical carcinoma.

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