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> p38 delta / MAPK13 Protein p38 delta / MAPK13 Protein
Mitogen-Activated Protein Kinase 13
p38 delta / MAPK13 Products
p38 delta / MAPK13 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| p38 delta/MAPK13 | Human | p38 delta/MAPK13 Protein, Recombinant, with GST Tag | 10747-H09B |
p38 delta / MAPK13 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| p38 delta/MAPK13 | Human | Human p38 delta/MAPK13 cDNA Clone / ORF Clone | HG10747-M |
p38 delta / MAPK13 Related Areas
Enzyme>>Protein Kinase>>Intracellular Kinase>>Mitogen-Activated Protein Kinase (MAPK)>>p38 delta/MAPK13
Signal Transduction>>Protein Kinase>>Intracellular Kinase>>Mitogen-Activated Protein Kinase (MAPK)>>p38 delta/MAPK13
p38 delta / MAPK13 Alternative Names
p38 delta, MAPK13, RP1-179N16.4, MGC99536, PRKM13, SAPK4, p38delta [Homo sapiens]
p38 delta, Mapk13, RP24-313J18.2, SAPK4, Serk4 [Mus musculus]
p38 delta / MAPK13 Related Products
Protein Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| ERK2/MAPK1/MAPK2 | Human | ERK2/MAPK1 Protein, Recombinant, With GST Tag |
| JNK1/MAPK8 | Human | JNK1/MAPK8 Protein, Recombinant |
| JNK2/MAPK9 | Human | JNK2/MAPK9 Protein, Recombinant |
| p38 alpha/MAPK14 | Human | p38 alpha/MAPK14 Protein, Recombinant |
| p38 alpha/MAPK14 | Human | p38 alpha/MAPK14 Protein, Recombinant |
| p38 alpha/MAPK14 | Human | p38 alpha/MAPK148 Protein, Recombinant |
| MAPKAPK3 | Human | MAPKAPK3 Protein, Recombinant |
cDNA Clone Products
p38 delta / MAPK13 Background
The p38 family of mitogen-activated protein kinases (MAPK) includes p38 alpha (SAPK2a, CSBP), p38 beta (SAPK2b), p38 delta (SAPK4), and p38 gamma (SAPK3/ERK6). p38 alpha and p38 beta are widely expressed p38 isoforms that are involved in regulation of cell proliferation, differentiation, development, and response to stress. p38 delta, also known as MAPK13, is a regulator of differentiation-dependent gene expression in keratinocytes, and been as a regulator of surface epithelia differentiation and apoptosis. p38 delta protein is upregulated in Cholangiocarcinoma (CC) relative to hepatocellularcarcinoma (HCC) and to normal biliary tract tissues. p38 delta is important for motility and invasion of CC cells, suggesting that p38 delta may play an important role in CC metastasis. p38 delta is expressed in the epidermis, suggesting a role for p38 delta in regulating differentiation. p38 delta is the major p38 isoform driving suprabasal involucrin gene expression and that p38 delta directly regulates ERK1/2 activity via formation of a p38 delta-ERK1/2 complex. Recent emerging evidence suggests that the p38 stress MAPK pathway may function as a tumor suppressor through regulating Ras-dependent and -independent proliferation, transformation, invasion and cell death by isoform-specific mechanisms. p38 delta has important role in promoting cell proliferation and tumor development in epidermis and may have therapeutic implication for skin cancer.
p38 delta / MAPK13 Related Studies
- Efimova T, et al. (2003) A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formation. J Biol Chem. 278(36): 34277-85.
- Eckert RL, et al. (2003) p38 Mitogen-activated protein kinases on the body surface--a function for p38 delta. J Invest Dermatol. 120(5): 823-8.
- Loesch M, et al. (2008) The p38 MAPK stress pathway as a tumor suppressor or more? Front Biosci. 13: 3581-93.
- Schindler EM, et al. (2009) p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice. Cancer Res. 69(11): 4648-55.
- Tan FL, et al. (2010) p38delta/MAPK13 as a diagnostic marker for cholangiocarcinoma and its involvement in cell motility and invasion. Int J Cancer. 126(10): 2353-61.
