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NSFL1C  Protein, Antibody, ELISA Kit, cDNA Clone

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NSFL1C Related Pathways

    NSFL1C Related Protein, Antibody, cDNA Gene, and ELISA Kits

    NSFL1C Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    NSFL1C Summary & Protein Information

    NSFL1C Background

    Subunit structure: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono- ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP (By similarity).
    Subcellular location: Nucleus (By similarity). Golgi apparatus, Golgi stack (By similarity). Chromosome (By similarity). Note=Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks (By similarity).
    Post-translational: Phosphorylated during mitosis. Phosphorylation inhibits interaction with Golgi membranes and is required for the fragmentation of the Golgi stacks during mitosis (By similarity).
    Sequence similarity: Belongs to the NSFL1C family.
    Contains 1 SEP domain.
    Contains 1 UBX domain.
    General information above from UniProt

    NSFL1C Alternative Name

    P47,UBX1,UBXD10,UBXN2C,dJ776F14.1, [homo-sapiens]
    P47,Stxbp3a,Munc-18c, [mus-musculus]

    NSFL1C Related Studies

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