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Mouse Antibody Humanization Service

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Mouse Antibody Humanization Service

Service: Mouse Antibody Humanization
Technology: CDR grafting, computer aided modeling, CDR shaffling
Recombinant antibody expression
Production Host: HEK293 or CHO cell transient transfection for antibody production
Acceptance Criteria: Humanized mouse antibody with >85 human germline antibody identity, and with
similar antigen bingding affinity to original mouse antibody,
Timeline: 6~10 weeks from mouse antibody sequence to mg of humanization antibody
1 week from antibody humanization design and gene optimization
1 week for gene synthesis
1-2 weeks for vector construction and plasmid production
2-4 weeks for transient transfection, antibody purification, QC testing
1 week for affinity analysis
Deliverable: 4~16 humanized antibody sequences
1 – 5 mg purified antibody for each molecule
Larger quantity of antibody production can be requested
(please refer to our antibody production service).
Applications: therapeutic antibody discovery & development
Quotation: on-line request form or e-mail request to CRO-service@sinobiological.com

Track Records & Key Facts

  • • > 300 Staff
  • • > 80 Bioreactors
  • • > 30 Purification System
  • • > 10,000 Mab Production
  • • > 5000 Protein Bulks
  • • > 5000 antibody development
  • • 1-100mg Mab Production in 3-6 weeks
  • • 1-10 g Mab Production in 6-8 weeks
  • • Preferred CRO Partner for Multiple Top-10 Pharmas
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Mouse Monoclonal Antibody (Mab) Humanization Service Description

Since the early 90's, mouse monoclonal antibody humanization technology has made significant contribution in therapeutic antibody product development and commercialization. With efforts from many scientists, antibody humanization techniques have been greatly improved and optimized. With the support of advanced process and engineering technology, antibody humanization now becomes routine practice, although it is still a challenging task that involves lots of hard work.

As therapeutic antibody development becomes the center of biological development, more biotech companies and research institutions are rushing into discovering and developing new antibody products. Humanization of mouse and rabbit neutralizing antibody candidates becomes a critical step in limiting antibody development. Due to the complexity of the technology...... <Learn More>

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"