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Mouse Wnt-1  Protein

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Wnt-1

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Wnt-1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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Wnt-1 Summary & Protein Information

Wnt-1 Related Information

Wnt-1 Background

Subunit structure: Interacts with PORCN. Interacts with RSPO1, RSPO2 and RSPO3 (By similarity). Interacts with WLS (By similarity). {ECO:0000250}.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Post-translational: Palmitoylation at Ser-224 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface. A palmitoylation site was proposed at Cys-93, but it was later shown that this cysteine is engaged in a disulfide bond. {ECO:0000269|PubMed:21244856}.
Involvement in disease: DISEASE: Osteoporosis (OSTEOP) [MIM:166710]: A systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs. {ECO:0000269|PubMed:23499309, ECO:0000269|PubMed:23656646}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; DISEASE: Osteogenesis imperfecta 15 (OI15) [MIM:615220]: An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI15 is characterized by early-onset recurrent fractures, bone deformity, significant reduction of bone density, short stature, and, in some patients, blue sclerae. Tooth development and hearing are normal. Learning and developmental delays and brain anomalies have been observed in some patients. {ECO:0000269|PubMed:23434763, ECO:0000269|PubMed:23499309, ECO:0000269|PubMed:23499310, ECO:0000269|PubMed:23656646}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Belongs to the Wnt family. {ECO:0000305}.
General information above from UniProt

Wnt-1 Alternative Name

Wnt-1 Related Studies

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