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MAP2K5/MEK5  Protein, Antibody, ELISA Kit, cDNA Clone

MAP2K5/MEK5 Related Area

MAP2K5/MEK5 Related Protein, Antibody, cDNA Gene, and ELISA Kits

MAP2K5/MEK5 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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MAP2K5/MEK5 Summary & Protein Information

MAP2K5/MEK5 Background

Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cofactor: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Subunit structure: Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity). Interacts with Yersinia yopJ. {ECO:0000250, ECO:0000269|PubMed:16728640, ECO:0000269|PubMed:7759517, ECO:0000269|Ref.12, ECO:0000269|Ref.13}.
Domain: Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the PB1 domain. This domain also mediates interactions with SQSTM1 and PARD6A (By similarity). {ECO:0000250}.
Tissue specificity: Expressed in many adult tissues. Abundant in heart and skeletal muscle.
Post-translational: Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. {ECO:0000250}.; Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway. {ECO:0000269|PubMed:16728640, ECO:0000269|PubMed:7759517}.
Sequence similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. {ECO:0000305}.; Contains 1 PB1 domain. {ECO:0000255|PROSITE-ProRule:PRU01081}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
General information above from UniProt

MAP2K5/MEK5 Alternative Name

MEK5,MAPKK5,PRKMK5,HsT17454, [homo-sapiens]
MEK5,Mapkk5,Prkmk5,AI324775,AI428457, [mus-musculus]

MAP2K5/MEK5 Related Studies

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