IL2: IL2 Protein | IL2 Antibody

IL2 Gene family

IL2 Background

Interleukin-2, also known as T-cell growth factor, TCGF, Aldesleukin and IL2, is a secreted protein which belongs to the&nbsp;IL-2 family. Interleukin-2 / IL-2 was the first interleukin molecule to be discovered. Interleukin-2 / IL-2 molecule was first purified to homogeneity by immunoaffinity chromatography by Kendall Smith and his team at Dartmouth Medical School. Interleukin-2 / IL-2 was also the first cytokine shown to mediate its effects via a specific IL-2 receptor, and it was also the first interleukin to be cloned and expressed from a complementary DNA (cDNA) library. Interleukin-2 / IL-2 was designated number 2 because Smith's data at the time indicated that IL-1, produced by&nbsp;macrophages, facilitates IL-2 production by T lymphocytes (T cells). <br> Interleukin-2 / IL-2 is produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Interleukin-2 / IL-2 is normally produced by the body during an immune response. When environmental substances (molecules or microbes) gain access to the body, these substances (termed antigens) are recognized as foreign by antigen receptors that are expressed on the surface of lymphocytes. Antigen binding to the T cell receptor (TCR) stimulates the secretion of Interleukin-2 / IL-2, and the expression of IL-2 receptors IL-2R. The IL-2 / IL-2R interaction then stimulates the growth, differentiation and survival of antigen-selected cytotoxic T cells via the activation of the expression of specific genes. Interleukin-2 / IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. The World Reference Standard for Interleukin-2 / IL-2 is produced by the National Institute of Biological Standards and Control in the UK. A recombinant form of Interleukin-2 / IL-2 for clinical use is manufactured by Chiron Corporation with the brand name Proleukin. It has been approved by the Food and Drug Administration (FDA) for the treatment of cancers (malignant melanoma, renal cell cancer), and is in clinical trials for the treatment of chronic viral infections, and as a booster (adjuvant) for vaccines. The use of Interleukin-2 / IL-2 in HIV therapy has been found to be ineffective.

Reference for IL2

  • Smith KA, et al.,1980, J. Exp. Med.151(6): 1551-6.
  • Smith KA, et al.,1980, Nature. 287(5785): 853-5.
  • Taniguchi T, et al.,1983, Nature. 302(5906): 305.
  • Cantrell DA, et al.,1984, Science.224(4655): 1312-6.
  • Smith KA, et al.,1988, Science.240(4856): 1169-76.
  • Wang X. et al., 2005, Science 310:1159-63.

IL2 Protein

IL2 protein function

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

IL2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    153.00
  • Mass (Da)
    17.00

IL2 Antibody

There are 19 IL2 antibodies which are validated in multiple tissues with various applications, including ELISA, FCM, WB, IHC-P. There are 16 IL2 antibody for ELISA, 2 IL2 antibody for FCM, 2 IL2 antibody for WB, 1 IL2 antibody for IHC-P. Among all these IL2 antibodies, there are 4 anti-IL2 mouse monoclonal antibodies , 5 anti-IL2 rabbit monoclonal antibodies , 10 anti-IL2 rabbit polyclonal antibodies . All the IL2 anbodies are produced in house and all are in stock. IL2 antibody customerized service is available.

IL2 Gene

IL2 gene / cDNA is a protein-coding gene which located on 4q27. The IL2 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, and rat.112 organisms have orthologs with human gene IL2.