Interferon alpha 7 / IFNA7 Protein (Cytokine)

Interferon, alpha 7 Protein Datasheet

Interferon alpha 7 / IFNA7 Protein Product Information

• Synonym: IFN-alphaJ, IFNA-J
• Protein Construction: A DNA sequence encoding the human IFNA7 (P01567) ( Cys 24-Asp 189 ) was fused with the Fc region of human IgG1 at the N-terminus.
• Source: Human
• Expression Host: Human Cells

Interferon alpha 7 / IFNA7 Protein QC Testing

• Purity: > 85 % as determined by SDS-PAGE.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Glu
• Molecular Mass: The recombinant human IFNA7/Fc chimera is a disulfide-linked homodimer. The reduced monomer comprises 427 amino acids with a predicted molecular mass of 48 kDa. rh IFNA7/Fc monomer migrates as an approximately 50 kDa band in SDS-PAGE under reducing conditions.
• Formulation: Lyophilized from sterile PBS , pH 7.4
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.
• SDS-PAGE: Interferon alpha 7 / IFNA7 protein

Interferon alpha 7 / IFNA7 Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Interferon alpha 7 / IFNA7 Protein Description

Interferons belong to the group of the regulatory glycoproteins, of low molecular mass. They are the products of infected cell-genome, but not virus, as a consequence of the cause answer by different inductors. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. IFNs have other functions: they activate immune cells, such as natural killer cells and macrophages; they increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes; and they increase the ability of uninfected host cells to resist new infection by virus. Certain host symptoms, such as aching muscles and fever, are related to the production of IFNs during infection. Human IFN are divided on the sequence of amino-acids into three groups: Alpha, Beta and Gamma Interferons. Interferon alpha-7(IFNA7) is a member of the Interferon family.

References

1. De Veer. et al., 2001, Journal of leukocyte biology. 69 (6): 912-20
2. Liu YJ. et al., 2005,  Annu Rev Immunol. 23: 275-306
3. Fensterl V. et al., 2009, Biofactors. 35 (1): 14-20