Nonstructural protein 2 / NS2: Nonstructural protein 2 / NS2 Protein | Nonstructural protein 2 / NS2 Antibody

Nonstructural protein 2 / NS2 Background

Non-structural protein 2 (NS2) plays a crucial role in the hepatitis C virus (HCV) assembly. NS2 was predicted to be composed of three transmembrane (TM) segments.Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is a hydrophobic, transmembrane protein that is required not only for NS2-NS3 cleavage, but also for infectious virus production.NS2 protein is essential for hepatitis C virus (HCV) replication. NS2 protein was expressed and purified. Aptamers against NS2 protein were raised and antiviral effects of the aptamers were examined. The non-structural protein NS2, also called nuclear export protein, of influenza A virus contains a leucine-rich nuclear-export signal that could guide viral ribonucleoproteins to cross the nuclear pore complex (NPC) and complete directional nucleocytoplasmic trafficking.

Reference for Nonstructural protein 2 / NS2

  • Hung HM, et al. (2016) Theoretical study of the interactions between the first transmembrane segment of ns2 protein and a popc lipid bilayer. Biophys Chem 217(1-7.
  • Gao Y, et al. (2014) Inhibition of hepatitis c virus infection by DNA aptamer against ns2 protein. PLoS One 9(2), e90333.
  • Suzuki R, et al. (2013) Signal peptidase complex subunit 1 participates in the assembly of hepatitis c virus through an interaction with e2 and ns2. PLoS Pathog 9(8), e1003589.
  • Chen J, et al. (2010) Human cellular protein nucleoporin hnup98 interacts with influenza a virus ns2/nuclear export protein and overexpression of its glfg repeat domain can inhibit virus propagation. J Gen Virol 91(Pt 10), 2474-2484.