Immune Checkpoint Pathways

Co-stimulatory Immune Checkpoint Pathway

Immune checkpoint targets	Immune checkpoint pathways
CD155 / PVR, CD226 / DNAM-1	CD266 & CD155 immune checkpoint pathway
CD40 / TNFRSF5, CD40L / CD154 / TNFSF5	CD40 & CD40L immune checkpoint pathway
OX40 / CD134, OX-40L / TNFSF4 / CD252	OX40 & OX40L immune checkpoint pathway
HVEM / TNFRSF14, TNFSF14 / LIGHT / CD258	HVEM & LIGHT immune checkpoint pathway
CD28 / TP44, CD80 / B7-1, CD86 / B7-2	CD28 & CD80 (CD86) immune checkpoint pathway
GITR / TNFRSF18, GITR Ligand/TNFSF18	GITR & GITR Ligand immune checkpoint pathway
CD27, CD70 / CD27L / TNFSF7	CD27 & CD70 immune checkpoint pathway
CD137 / 4-1BB, 4-1BBL / CD137L	4-1BB & 4-1BBL immune checkpoint pathway
ICOS / AILIM / CD278 , ICOS Ligand / B7-H2	ICOS & ICOS Ligand immune checkpoint pathway

Immune checkpoint targets	Immune checkpoint pathways
PD1 / PDCD1 / CD279, PD-L1 / B7-H1 / CD274	PD1 & PD-L1 immune checkpoint pathway
CTLA-4 / CD152, CD80 / B7-1, CD86 / B7-2	CTLA-4 & CD80 (CD86) immune checkpoint pathway
B7-H3 / CD276	B7-H3 / CD276 immune checkpoint pathway
B7-H4 / B7S1 / B7x	B7-H4 / B7S1 / B7x immune checkpoint pathway
HVEM / TNFRSF14, BTLA	HVEM & BTLA immune checkpoint pathway
HVEM / TNFRSF14, CD160	HVEM & CD160 immune checkpoint pathway
LAG3 / CD223 / Lymphocyte activation gene 3	LAG3 / CD223 / Lymphocyte activation gene 3 immune checkpoint pathway
Galectin-9 / LGALS9, TIM-3 / HAVCR2	Galectin-9 & TIM-3 immune checkpoint pathway
Indoleamine 2,3-dioxygenase/IDO	Indoleamine 2,3-dioxygenase/IDO immune checkpoint pathway
VISTA / B7-H5 / GI24	VISTA / B7-H5 / GI24 immune checkpoint pathway
CEACAM1 / CD66a	CEACAM1 / CD66a immune checkpoint pathway
SIRP alpha / CD172a, CD47	SIRP alpha & CD47 immune checkpoint pathway
2B4 / CD244, CD48 / SLAMF2	2B4 & CD48 immune checkpoint pathway
TIGIT / VSTM3, CD155 / PVR	TIGIT & CD155 immune checkpoint pathway