IL-5: IL-5 Protein | IL-5 Antibody

IL-5 Gene family

IL-5 Background

Interleukin 5 (IL-5) is a member of the interleukin family with length of 115 amino acids. Interleukins are a group of cytokines (secreted proteins / signaling molecules) that were first seen to be expressed by white blood cells (leukocytes) and has been found in a wide variety of body cells. Interleukin 5 or IL-5 is produced by T helper-2 cells and mast cells. It helps to stimulate B cell growth and increase immunoglobulin secretion and is considered as a key mediator in eosinophil activation. Interleukin 5 (IL-5) has long been associated with several allergic diseases, including allergic rhinitis and asthma. Growth in the number of circulating, airway tissue, and induced sputum eosinophils have been observed in patients with these diseases. IL-5 also had something with the terminally differentiated granulocyte eosinophils. IL-5 was originally found as an eosinophil colony stimulating factor. It has been proved to be a major regulator of eosinophil accumulation in tissues, and can modulate eosinophil behavior at every stage from maturation to survival.

Reference for IL-5

  • Milburn MV, et al. (1993) A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5. Nature. 363(6425): 172-176.
  • Lee JS, et al. (1989) The IL-4 and IL-5 genes are closely linked and are part of a cytokine gene cluster on mouse chromosome 11. Somat Cell Mol Genet. 15(2): 143-152.
  • Woodcock JM, et al. (1994) Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 13 (21): 5176-85.

IL-5 Protein

IL-5 protein function

Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.

IL-5 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

IL-5 Antibody

There are 13 IL-5 antibodies which are validated in multiple tissues with various applications, including ELISA, ELISA(Cap), ELISA(Det), Neutralization, WB. There are 9 IL-5 antibody for ELISA, 2 IL-5 antibody for ELISA(Cap), 1 IL-5 antibody for ELISA(Det), 1 IL-5 antibody for Neutralization, 2 IL-5 antibody for WB. Among all these IL-5 antibodies, there are 2 anti-IL-5 mouse monoclonal antibodies , 6 anti-IL-5 rabbit monoclonal antibodies , 5 anti-IL-5 rabbit polyclonal antibodies . All the IL-5 anbodies are produced in house and all are in stock. IL-5 antibody customerized service is available.

IL-5 Gene

IL5 gene / cDNA is a protein-coding gene which located on 5q31.1. The IL5 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.116 organisms have orthologs with human gene IL5.