Anti-ICOS ligand Antibody (FITC)

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Anti-ICOS ligand Antibody (FITC) (Mouse Monoclonal antibody) General Information

Product name
Anti-ICOS ligand Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human ICOS ligand
Immunogen
Recombinant Human ICOS Ligand / B7-H2 protein (Catalog#11559-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ICOS Ligand / B7-H2 (rh ICOS Ligand / B7-H2; Catalog#11559-H08H; NP_056074.1; Met1-Ser258) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Mouse IgG1 Clone #01
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-ICOS ligand Antibody (FITC) (Mouse Monoclonal antibody) Images

Flow cytometric analysis of ICOSLG(CD275) expression on RPMI8226 cells.

Anti-ICOS ligand Antibody (FITC): Alternative Names

Anti-B7-h2 Antibody; Anti-B7H2 Antibody; Anti-B7RP-1 Antibody; Anti-B7RP1 Antibody; Anti-CD275 Antibody; Anti-GL50 Antibody; Anti-ICOS ligand Antibody; Anti-ICOS-L Antibody; Anti-ICOSL Antibody; Anti-ICOSLG Antibody; Anti-LICOS Antibody

ICOS ligand Background Information

Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.
Full Name
inducible T-cell co-stimulator ligand
References
  • Flesch IE. (2002) Inducible costimulator-ligand (ICOS-L). J Biol Regul Homeost Agents. 16(3): 217-9.
  • Kajiwara K, et al. (2009) Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int. 58(4): 573-83.
  • Wong SC, et al. (2009) Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity. Cell Immunol. 256(1-2): 64-71.

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