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Human FcERI/FCER1A Protein, Antibody, Gene cDNA Clone & ELISA Kit

Product NameMoleculeSpeciesCat No.PackagePrice 
Human FcERI / FCER1A Protein (His Tag)FcERI/FCER1AHuman
50 µg
100 µg
Product NameApplication(key)Reactivity(key)Cat No.PackagePrice 
FcERI / FCER1A Antibody, Rabbit PAb, Antigen Affinity PurifiedELISA  WB  IF  ICC/IF  Human
50 µg
200 µg
100 µg

Additional Human Fc Receptor Products

Additional Specie Products of Fc Receptor

Human Fc Receptor FCER1A Background

FcERI, also known as FCER1A, is the alpha subunit of the immunoglobulin epsilon receptor (IgE receptor). IgE receptor is a high affinity IgE receptor which plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. IgE receptor is comprised of an alpha subunit(FcERI), a beta subunit, and two gamma subunits. FcERI is glycosylated and contains 2 Ig-like (immunoglobulin-like) domains.

Human Fc Receptor FcERI/FCER1A Reference

  • Shikanai T, et al. (2002) Sequence variants in the FcepsilonRI alpha chain gene. J Appl Physiol. 93(1):37-41.
  • Sada K, et al. (2002) Regulation of FcepsilonRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells. Blood. 100(6):2138-44.
  • Takahashi K, et al. (2003) Transcriptional regulation of the human high affinity IgE receptor alpha-chain gene. Mol Immunol. 38(16-18):1193-9.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"