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Human CD89/FCAR Protein, Antibody, Gene cDNA Clone & ELISA Kit

Product NameMoleculeSpeciesCat No.PackagePrice 
Human CD89 / FCAR Protein (His Tag)CD89/FCARHuman
50 µg
100 µg
Product NameApplication(key)Reactivity(key)Cat No.PackagePrice 
CD89 / FCAR Antibody (APC), Mouse MAbFCM  Human
50 Tests
100 Tests
CD89 / FCAR Antibody, Rabbit PAbELISA  Human
400 µg
200 µg
100 µg
CD89 / FCAR Antibody, Rabbit PAb, Antigen Affinity PurifiedELISA  Human
50 µg
200 µg
100 µg
CD89 / FCAR Antibody, Mouse MAbELISA  FCM  Human
50 µg
200 µg
100 µg
CD89 / FCAR Antibody, Rabbit MAbELISA  Human
50 µg
100 µg
CD89 / FCAR Antibody (PE), Mouse MAbFCM  Human
50 Tests
100 Tests
CD89 / FCAR Antibody (FITC), Mouse MAbFCM  Human
50 Tests
100 Tests
Product NameMoleculeSpeciesCat No.Price 
Human CD89/FCAR transcript variant 1 Gene ORF cDNA clone expression plasmid, N-HA tagCD89/FCARHuman
Human CD89/FCAR transcript variant 1 Gene ORF cDNA clone expression plasmid, C-HA tagCD89/FCARHuman
Human CD89/FCAR transcript variant 1 Gene ORF cDNA clone expression plasmid, C-His tagCD89/FCARHuman
Human CD89/FCAR transcript variant 1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tagCD89/FCARHuman
Human CD89/FCAR transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tagCD89/FCARHuman
Human CD89/FCAR transcript variant 1 Gene ORF cDNA clone in cloning vectorCD89/FCARHuman
Human CD89/FCAR transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tagCD89/FCARHuman
Human CD89/FCAR transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Myc tagCD89/FCARHuman
Human CD89/FCAR transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His tagCD89/FCARHuman
Human CD89/FCAR transcript variant 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tagCD89/FCARHuman
Human CD89/FCAR transcript variant 1 Gene ORF cDNA clone expression plasmidCD89/FCARHuman
Human CD89/FCAR transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Myc tagCD89/FCARHuman
Human CD89/FCAR transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag tagCD89/FCARHuman
Product NameAntigenApplicationReactivityCat No.PackagePrice 
Human CD89 / FCAR ELISA Pair SetCD89/FCARELISA  Human
5 Plates
15 Plates

Additional Human Fc Receptor Products

Additional Specie Products of Fc Receptor

Human Fc Receptor FCAR Background

FCAR, also called FcαRI or CD89, is a type I  transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.

Human Fc Receptor CD89/FCAR Reference

  1. Maliszewski, C.R. et al., 1990, J. Exp. Med. 172: 1665-1672.
  2. Launay, P. et al., 1999, J. Biol. Chem. 274: 7216-7225.
  3. Monteiro, R.C. et al., 2003, Annu. Rev. Immunol. 21: 177-204.
  4. Otten, M.A. et al., 2005, J. Immunol. 174: 5472-5480.
  5. Pasquier, B. et al., 2005, Immunity. 22:31-42.
  6. Kanamaru, Y. et al., 2007, Blood. 109: 203-211.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"