DDR1 Matched ELISA Antibody Pair Set,Human

1/1
Price:
Size:
Number:

DDR1 Matched ELISA Antibody Pair Set,Human General Information

Product name
DDR1 Matched ELISA Antibody Pair Set,Human
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Human DDR1
Assay range
56.25-3600 pg/mL
Materials provided
1. Capture Antibody 0.5 mg/mL of rabbit anti-Human DDR1 / MCK10 / CD167 monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 10730-R205)
2. Detection Antibody 0.2 mg/mL of rabbit anti-Human DDR1 / MCK10 / CD167 monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.5 μg/mL in detection antibody dilution buffer before use. (Catalog: # 10730-R017)
3. Standard Each vial contains 155 ng of recombinant Human DDR1 / MCK10 / CD167. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 3600 pg/mL is recommended.
Product overview
This DDR1 Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human DDR1 . It contains Human DDR1 capture antibody, Human DDR1 detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human DDR1 protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

DDR1 Matched ELISA Antibody Pair Set,Human Images

DDR1 Matched ELISA Antibody Pair Set,Human: Alternative Names

CAK Matched ELISA Antibody Pair Set, Human; CD167 Matched ELISA Antibody Pair Set, Human; DDR Matched ELISA Antibody Pair Set, Human; EDDR1 Matched ELISA Antibody Pair Set, Human; HGK2 Matched ELISA Antibody Pair Set, Human; MCK10 Matched ELISA Antibody Pair Set, Human; NEP Matched ELISA Antibody Pair Set, Human; NTRK4 Matched ELISA Antibody Pair Set, Human; PTK3 Matched ELISA Antibody Pair Set, Human; PTK3A Matched ELISA Antibody Pair Set, Human; RTK6 Matched ELISA Antibody Pair Set, Human; TRKE Matched ELISA Antibody Pair Set, Human

DDR1 Background Information

Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 1 (MCK1), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK1/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK1/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.
Full Name
discoidin domain receptor tyrosine kinase 1
References
  • Hou G, et al. (2001) The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair. J Clin Invest. 107(6): 727-35.
  • Ongusaha PP, et al. (2003) p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop. EMBO J. 22(6): 1289-301.
  • Jönsson M, et al. (2001) Repression of Wnt-5a impairs DDR1 phosphorylation and modifies adhesion and migration of mammary cells. J Cell Sci. 114(11): 2043-53.
Add to Cart Successfully Add to Cart Failed Shopping cart is being updated, please wait