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Human TFRC/CD71  Antibody

All TFRC Reagents

Reactivity: Human  
Application: FCM  
11020-R040-P-25
11020-R040-P-100
25 Test 
100 Tests 
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Reactivity: Human  
Application: FCM  
11020-MM03-50
11020-MM03-200
11020-MM03-100
50 µg 
200 µg 
100 µg 
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Reactivity: Human  
Application: IHC-P  IP  
11020-R016-50
11020-R016-100
50 µg 
100 µg 
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Reactivity: Human  
Application: FCM  
11020-MM04-P-25
11020-MM04-P-100
25 Test 
100 Tests 
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Reactivity: Human  
Application: FCM  
11020-MM03-A-25
11020-MM03-A-100
25 Test 
100 Tests 
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Reactivity: Human  
Application: FCM  IF  ICC/IF  
11020-R040-50
11020-R040-100
50 µg 
100 µg 
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Reactivity: Human  
Application: FCM  
11020-MM04-F-25
11020-MM04-F-100
25 Test 
100 Tests 
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Reactivity: Human  
Application: FCM  
11020-R040-C-25
11020-R040-C-100
25 Test 
100 Tests 
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Reactivity: Human  
Application: FCM  
11020-MM03-F-25
11020-MM03-F-100
25 Test 
100 Tests 
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Reactivity: Human  
Application: 
11020-MM03-C-25
11020-MM03-C-100
25 Test 
100 Tests 
Add to Cart
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Reactivity: Human  
Application: FCM  
11020-MM03-P-25
11020-MM03-P-100
25 Test 
100 Tests 
Add to Cart
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Reactivity: Human  
Application: 
11020-MM04-C-25
11020-MM04-C-100
25 Test 
100 Tests 
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Reactivity: Human  
Application: FCM  
11020-MM04-50
11020-MM04-200
11020-MM04-100
50 µg 
200 µg 
100 µg 
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Reactivity: Human  
Application: FCM  
11020-MM04-A-25
11020-MM04-A-100
25 Test 
100 Tests 
Add to Cart
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Reactivity: Human  
Application: ELISA  
11020-MM02-50
11020-MM02-200
11020-MM02-100
50 µg 
200 µg 
100 µg 
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    Reactivity: Human  
    Application: ELISA  WB  IHC-P  IP  
    11020-RP02-50
    11020-RP02-100
    50 µg 
    100 µg 
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    Reactivity: Human  
    Application: ELISA  WB  IP  
    11020-R001-50
    11020-R001-100
    50 µg 
    100 µg 
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    Reactivity: Human  
    Application: ELISA  WB  
    11020-RP01-400
    11020-RP01-200
    11020-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    Reactivity: Human  
    Application: FCM  
    11020-R040-A-25
    11020-R040-A-100
    25 Test 
    100 Tests 
    Add to Cart
    • Slide 1
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    Reactivity: Human  
    Application: FCM  
    11020-R040-F-25
    11020-R040-F-100
    25 Test 
    100 Tests 
    Add to Cart
    • Slide 1

    Browse TFRC/CD71 Products by

    TFRC/CD71 Related Area

    TFRC/CD71 Related Pathways

      TFRC/CD71 Summary & Protein Information

      TFRC/CD71 Background

      Gene Summary: This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis.
      General information above from NCBI
      Subunit structure: Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:17287727}.
      Subcellular location: Cell membrane {ECO:0000269|PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.; Transferrin receptor protein 1, serum form: Secreted.
      Induction: Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.
      Post-translational: N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated. {ECO:0000269|PubMed:1421756, ECO:0000269|PubMed:1421757, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:3582362}.; Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).; Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation. {ECO:0000269|PubMed:3582362}.
      Sequence similarity: Belongs to the peptidase M28 family. M28B subfamily. {ECO:0000305}.; Contains 1 PA (protease associated) domain. {ECO:0000305}.
      General information above from UniProt

      Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p90, CD71 and TFRC, is a single-pass type II membrane protein which belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.

      TFRC/CD71 Alternative Name

      TR,T9,TFR,CD71,TFR1,TRFR,P90, [homo-sapiens]
      TFR,Transferrin Receptor,CD71,TFR1,TFRC,TRFR, [human]
      Mtvr-1,TFR,Transferrin Receptor,Trfr,2610028K12Rik,AI195355,AI426448,AU015758,TR,CD71,E430033M20Rik,Mtvr1,p90,TFR1,Tfrc, [mouse]
      Tr,TFR,p90,CD71,TFR1,Trfr,Mtvr1,Mtvr-1,AI195355,AI426448,AU015758,2610028K12Rik,E430033M20Rik, [mus-musculus]

      TFRC/CD71 Related Studies

    • Douabin-Gicquel V., et al., 2001,Hum. Genet. 109:393-401.
    • Ryschich,E. et al., 2004,Eur J Cancer. 40 (9):1418-22.
    • Tosoni D., et al., 2005, Cell 123:875-888.
    • Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.
    • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"