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Human TNF-alpha/TNFA/TNFSF2  Antibody

All TNFA Reagents

TNF-alpha/TNFA/TNFSF2
Reactivity: Human  
Application: FCM  
10602-R101-F-25
10602-R101-F-100
25 Test 
100 Tests 
Add to Cart
  • Slide 1
Reactivity: Human  
Application: FCM  
10602-R101-A-25
10602-R101-A-100
25 Test 
100 Tests 
Add to Cart
  • Slide 1
Reactivity: Human  
Application: B/N  
10602-R10N1-500
10602-R10N1-200
500 µg 
200 µg 
Add to Cart
  • Slide 1
Reactivity: Human  
Application: ELISA  WB  
10602-RP03-200
10602-RP03-100
200 µg 
100 µg 
Add to Cart
  • Slide 1
Reactivity: Human  
Application: ELISA  
10602-T16-50
10602-T16-200
10602-T16-100
50 µg 
200 µg 
100 µg 
Add to Cart
    Reactivity: Human  
    Application: ELISA  WB  IP  
    10602-RP02-50
    10602-RP02-200
    10602-RP02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    • Slide 1
    • Slide 1
    Reactivity: Human  
    Application: FCM  
    10602-MM01-F-25
    10602-MM01-F-100
    25 Test 
    100 Tests 
    Add to Cart
    • Slide 1
    Reactivity: Human  
    Application: FCM  
    10602-R101-P-25
    10602-R101-P-100
    25 Test 
    100 Tests 
    Add to Cart
    • Slide 1
    • Slide 1
    Reactivity: Human  
    Application: ELISA  
    10602-RP01-400
    10602-RP01-200
    10602-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
      Reactivity: Human  
      Application: 
      10602-MM08-50
      10602-MM08-200
      10602-MM08-100
      10602-MM08-1
      50 µg 
      200 µg 
      100 µg 
      1 mg 
      Add to Cart
        Reactivity: Human  
        Application: B/N  
        10602-MM0N1-500
        10602-MM0N1-200
        500 µg 
        200 µg 
        Add to Cart
        • Slide 1
        Reactivity: Human  
        Application: ELISA  
        10602-R211-50
        10602-R211-100
        50 µg 
        100 µg 
        Add to Cart
          Reactivity: Human  
          Application: ELISA  
          10602-RE23-50
          10602-RE23-100
          50 µg 
          100 µg 
          Add to Cart
            Reactivity: Human  
            Application: FCM  
            10602-R101-50
            10602-R101-100
            50 µg 
            100 µg 
            Add to Cart
            • Slide 1
            Reactivity: Human  
            Application: ELISA  FCM  
            10602-MM01-50
            10602-MM01-100
            10602-MM01-1
            50 µg 
            100 µg 
            1 mg 
            Add to Cart
            • Slide 1
            10602-H01HL-300 

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            TNF-alpha/TNFA/TNFSF2 Related Area

            TNF-alpha/TNFA/TNFSF2 Related Pathways

            TNF-alpha/TNFA/TNFSF2 Related Protein, Antibody, cDNA Gene, and ELISA Kits

            TNF-alpha/TNFA/TNFSF2 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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            TNF-alpha/TNFA/TNFSF2 Summary & Protein Information

            TNF-alpha/TNFA/TNFSF2 Related Information

            TNF-alpha/TNFA/TNFSF2 Background

            Gene Summary: Tumor necrosis factor (TNF) is a multifunctional proinflammatory cytokine secreted predominantly by monocytes/macrophages that has effects on lipid metabolism, coagulation, insulin resistance, and endothelial function. TNF was originally identified in mouse serum after injection with Mycobacterium bovis strain bacillus Calmette-Guerin (BCG) and endotoxin. Serum from such animals was cytotoxic or cytostatic to a number of mouse and human transformed cell lines and produced hemorrhagic necrosis and in some instances complete regression of certain transplanted tumors in mice
            General information above from NCBI
            Subunit structure: Homotrimer. Interacts with SPPL2B. {ECO:0000269|PubMed:16829951}.
            Subcellular location: Cell membrane {ECO:0000269|PubMed:16829952}; Single-pass type II membrane protein {ECO:0000269|PubMed:16829952}.; Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein.; Tumor necrosis factor, soluble form: Secreted.; C-domain 1: Secreted.; C-domain 2: Secreted.
            Post-translational: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space. {ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:9034191}.; The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1. {ECO:0000269|PubMed:10205166, ECO:0000269|PubMed:8597870}.; O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid. {ECO:0000269|PubMed:8631363}.
            Involvement in disease: DISEASE: Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). {ECO:0000269|PubMed:12746914}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
            Sequence similarity: Belongs to the tumor necrosis factor family. {ECO:0000305}.
            General information above from UniProt

            Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD120a; p55/60) and TNF-R2 (TNF receptor type 2; CD120b; p75/80), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.

            TNF-alpha Protein & Antibody

            Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

            TNF-alpha/TNFA/TNFSF2 Alternative Name

            TNF-alpha/TNFA/TNFSF2 Related Studies

          • Hector J, et al. (2007) TNF-alpha alters visfatin and adiponectin levels in human fat. Horm Metab Res. 39(4): 250-5.
          • Berthold-Losleben M, et al. (2008) The TNF-alpha System: Functional Aspects in Depression, Narcolepsy and Psychopharmacology. Curr Neuropharmacol. 6(3): 193-202.
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