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Human S100A12  Antibody

All S100A12 Reagents

Reactivity: Human  
Application: IHC-P  
11143-R133-50
11143-R133-100
50 µg 
100 µg 
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  • Slide 1
Reactivity: Human  
Application: ELISA  
11143-R001-50
11143-R001-100
50 µg 
100 µg 
Add to Cart
    Reactivity: Human  
    Application: ELISA  IHC-P  
    11143-RP02-50
    11143-RP02-200
    11143-RP02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    • Slide 1
    Reactivity: Human  
    Application: ELISA  
    11143-RP01-400
    11143-RP01-200
    11143-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart

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      S100A12 Related Area

      S100A12 Related Pathways

        S100A12 Summary & Protein Information

        S100A12 Background

        Gene Summary: The protein encoded by this S100A12 gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. [provided by RefSeq, Jul 2008]
        General information above from NCBI
        Subunit structure: Homodimer. Homooligomer (tetramer or hexamer) in the presence of calcium, zinc and copper ions. Interacts with AGER and both calcium and zinc are essential for the interaction. Interacts with CACYBP in a calcium-dependent manner. {ECO:0000269|PubMed:12042313, ECO:0000269|PubMed:19386136}.
        Domain: The hinge domain contributes significantly to its chemotactic properties. {ECO:0000269|PubMed:18292089}.
        Subcellular location: Secreted {ECO:0000269|PubMed:22811950}. Cytoplasm {ECO:0000269|PubMed:22811950}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22811950}. Cell membrane {ECO:0000269|PubMed:22811950}; Peripheral membrane protein {ECO:0000269|PubMed:22811950}. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule-mediated, alternative pathway.
        Tissue specificity: Predominantly expressed by neutrophils, monocytes and activated macrophages. Expressed by eosinophils and macrophages in asthmatic airways in regions where mast cells accumulate. Found in high concentrations in the serum of patients suffering from various inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and Kawasaki disease.
        Sequence similarity: Belongs to the S-100 family. {ECO:0000305}.; Contains 2 EF-hand domains. {ECO:0000255|PROSITE-ProRule:PRU00448}.
        General information above from UniProt

        S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. 

        Protein S100-A12, also known as S100 calcium-binding protein A12, Calcium-binding protein in amniotic fluid 1, Calgranulin-C, and S100A12, is a member of the S-101 family. Like the majority of S100 proteins, S100A12 is a dimer, with the interface between the two subunits being composed mostly of hydrophobic residues. The fold of S100A12 is similar to the other known crystal and solution structures of S100 proteins, except for the linker region between the two EF-hand motifs. S100A12 plays an important role in the inflammatory response.

        S100A12 Alternative Name

        CGRP,CAAF1,CAGC,ENRAGE,EN-RAGE,MRP6,p6,S100A12, [human]

        S100A12 Related Studies

      • Moroz, OV. et al., 2001, Acta Crystallogr D Biol Crystallogr. 57: 20-9.
      • Foell, D. et al., 2003, Lancet  361 (9365):1270-2.
      • Vogl, T. et al., 2004, Blood. 104: 4260-8.
      • Viemann, D. et al., 2005, Blood. 105: 2955-62.
      • Nakatani, Y. et al., 2005, Mediators Inflamm. 2005: 280-292.
      • Bjoerk, P. et al., 2009, PLoS Biol. 7: E97-E97.
      • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"