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Human IL-23A  Protein

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IL-23A

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    IL-23A Summary & Protein Information

    IL-23A Related Information

    IL-23A Background

    Subunit structure: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23. {ECO:0000269|PubMed:18680750}.
    Subcellular location: Secreted {ECO:0000269|PubMed:11114383}. Note=Secreted upon association with IL12B.
    Tissue specificity: Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). {ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:16424222}.
    Developmental stage: Expressed by newborns dendritic cells. {ECO:0000269|PubMed:16342235}.
    Induction: Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors. {ECO:0000269|PubMed:12421946, ECO:0000269|PubMed:15114670, ECO:0000269|PubMed:15486065, ECO:0000269|PubMed:15731058, ECO:0000269|PubMed:16424222, ECO:0000269|PubMed:16688182, ECO:0000269|PubMed:16751425}.
    Sequence similarity: Belongs to the IL-6 superfamily. {ECO:0000305}.
    General information above from UniProt

    IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35[10]. IL-23 is a heterodimeric cytokine, comprised a unique p19 subunit and p40 subunit, the latter of which is shared with IL-12. The receptor for IL-23 consists of IL-23R and IL-12Rβ1, the latter of which is also characteristic of IL-12. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway [11,12]. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis[13], primary biliary cirrhosis[14], and inflammatory bowel disease[15].

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    IL-23A Alternative Name

    SGRF,IL-23,IL-23A,IL23P19,p19, [homo-sapiens]
    IL-23,p19, [mus-musculus]

    IL-23A Related Studies

  • Ye X, Zhang L, Wang H, et al. The Role of IL-23/Th17 Pathway in Patients with Primary Immune Thrombocytopenia. Kuwana M, ed. PLoS ONE. 2015;10(1):e0117704.
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