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Human IL18BP / IL18BPa  Protein

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IL18BP / IL18BPa
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Expression host: Human Cells  
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Description: Active  
Expression host: Human Cells  
200 µg 
100 µg 
Add to Cart
  • Slide 1

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IL18BP / IL18BPa Summary & Protein Information

IL18BP / IL18BPa Related Information

IL18BP / IL18BPa Background

Gene Summary: The protein encoded by IL-18BP gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for IL-18BP gene. [provided by RefSeq, Feb 2011]
General information above from NCBI
Subcellular location: Secreted {ECO:0000305}.
Tissue specificity: Strongly expressed in heart, lung, placenta and spleen. {ECO:0000269|PubMed:10023777, ECO:0000269|PubMed:10094485}.
Post-translational: N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-103: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); N-glycan at Asn-147: dHex1Hex5HexNAc4. {ECO:0000269|PubMed:22171320}.
Sequence similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.
General information above from UniProt

Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.

IL18BP / IL18BPa Alternative Name

IL18BPa, [homo-sapiens]
IL18BP,IL18BPa, [human]
Igifbp,Il18bp,IL-18BP,MC54L, [mouse]
MC54L,Igifbp,IL-18BP, [mus-musculus]

IL18BP / IL18BPa Related Studies

  • Novick D, et al.. (2001) A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18. Cytokine. 14(6): 334-42.
  • Mazodier K, et al.. (2005) Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome. Blood. 106(10): 3483-9.
  • Akira S. (2000) The role of IL-18 in innate immunity. Curr Opin Immunol. 12(1): 59-63.