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Human IL6R/IL-6R/CD126  Protein

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Expression host: Human Cells  
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    IL6R/IL-6R/CD126 Summary & Protein Information

    IL6R/IL-6R/CD126 Related Information

    IL6R/IL-6R/CD126 Background

    Gene Summary: This IL6R gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL-6R is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this IL-6R are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
    General information above from NCBI
    Subunit structure: Hexamer of two molecules each of IL6, IL6R and IL6ST.
    Domain: The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.; The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    Subcellular location: Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.
    Tissue specificity: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.
    Post-translational: A short soluble form may also be released from the membrane by proteolysis.
    Sequence similarity: Belongs to the type I cytokine receptor family. Type 3 subfamily. {ECO:0000305}.; Contains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    IL6R/IL-6R/CD126 Alternative Name

    IL6Q,gp80,IL6RQ,IL-6RA, []
    CD126,IL6R,IL-6R,IL-6R-1,IL6RA,IL-6R-alpha,MGC104991, [human]

    IL6R/IL-6R/CD126 Related Studies

  • Barill S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51.
  • Kang KW, et al. (2007) Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells. Free Radic Biol Med. 42(2): 215-27.