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Human Furin  Antibody

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Furin

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Furin Related Protein, Antibody, cDNA Gene, and ELISA Kits

Furin Related Protein, Antibody, cDNA Gene, and ELISA Kits

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Furin Summary & Protein Information

Furin Background

Catalytic activity: Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and vWF from their respective precursors.
Cofactor: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Enzyme regulation: ENZYME REGULATION: Could be inhibited by the not secondly cleaved propeptide.
Subunit structure: Interacts with FLNA (By similarity). Binds to PACS1 which mediates TGN localization and connection to clathrin adapters. {ECO:0000250, ECO:0000269|PubMed:11331585}.
Domain: Contains a cytoplasmic domain responsible for its TGN localization and recycling from the cell surface.
Subcellular location: Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin.
Tissue specificity: Seems to be expressed ubiquitously.
Post-translational: The inhibition peptide, which plays the role of an intramolecular chaperone, is autocatalytically removed in the endoplasmic reticulum (ER) and remains non-covalently bound to furin as a potent autoinhibitor. Following transport to the trans Golgi, a second cleavage within the inhibition propeptide results in propeptide dissociation and furin activation. {ECO:0000269|PubMed:1629222}.; Phosphorylation is required for TGN localization of the endoprotease. In vivo, exists as di-, mono- and non-phosphorylated forms. {ECO:0000269|PubMed:8846780}.
Sequence similarity: Belongs to the peptidase S8 family. Furin subfamily. {ECO:0000305}.; Contains 1 peptidase S8 domain. {ECO:0000305}.
General information above from UniProt

Furin Alternative Name

FUR,PACE,SPC1,PCSK3, [homo-sapiens]
Fur,PACE,SPC1,Pcsk3,9130404I01Rik, [mus-musculus]

Furin Related Studies

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