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Human FUOM / fucose mutarotase / FucM  Gene / cDNA Clone

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FUOM / fucose mutarotase / FucM
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    FUOM / fucose mutarotase / FucM Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    FUOM / fucose mutarotase / FucM Summary & Protein Information

    FUOM / fucose mutarotase / FucM Background

    Catalytic activity: Alpha-L-fucose = beta-L-fucose. {ECO:0000269|PubMed:17602138}.
    Subunit structure: Mainly homodimer, but exists also as homotetramer, homooctamer, and homodecamer. The homodimeric form seems catalytically inactive (By similarity). {ECO:0000250}.
    Sequence similarity: Belongs to the RbsD / FucU family. {ECO:0000305}.
    General information above from UniProt

    FUOM, also known as fucose mutarotase and FucM, belongs to the RbsD / FucU family. FUOM is involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose has two isforms: alpha-L-fucose (29.5%) and beta-L-fucose (70.5%). The beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes. FUOM mainly exists as homodimer, but also functions as homotetramer, homooctamer, and homodecamer. FUOM's homodimeric form seems catalytically inactive.

    FUOM / fucose mutarotase / FucM Alternative Name

    FUCU,FucM,C10orf125, [homo-sapiens]
    fucose mutarotase,FUOM,RP11-122K13.9,C10orf125,FUCU,FucM,protein fucU homolog, [human]
    fucose mutarotase,Fuom,1810014F10Rik,Fucu,Le51,protein fucU homolog, [mouse]
    Fucu,Le51, [mus-musculus]

    FUOM / fucose mutarotase / FucM Related Studies

  • Deloukas P. et al., 2004, Nature. 429: 375-81.
  • Ota T. et al., 2004, Nat Genet. 36: 40-5.
  • Dongkyu Park. et al., 2007, Glycobiology. 17 (9): 955-62.
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