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Human FTLS / RSPO2  Antibody

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FTLS / RSPO2
13084-H02HL-300 

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FTLS / RSPO2 Related Area

FTLS / RSPO2 Related Protein, Antibody, cDNA Gene, and ELISA Kits

FTLS / RSPO2 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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FTLS / RSPO2 Summary & Protein Information

FTLS / RSPO2 Related Information

FTLS / RSPO2 Background

Subunit structure: Interacts with WNT1. Binds heparin (By similarity). Interacts with LGR4, LGR5 and LGR6. {ECO:0000250, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22615920}.
Domain: The FU repeat is required for activation and stabilization of beta-catenin. {ECO:0000250}.
Subcellular location: Secreted {ECO:0000250}.
Sequence similarity: Belongs to the R-spondin family. {ECO:0000305}.; Contains 1 FU (furin-like) repeat. {ECO:0000305}.; Contains 1 TSP type-1 domain. {ECO:0000255|PROSITE-ProRule:PRU00210}.
General information above from UniProt

R-spondin-2, also known as RSPO2, synergizes with Wnt to activate beta-catenin. RSPO2 is secreted proteins that regulate beta-catenin signaling. Activator of the beta-catenin signaling cascade leads to TCF-dependent gene activation. Action both in the canonical Wnt / beta- catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled / LRP receptors. Probably also acts as a ligand for frizzled and LRP receptors. The encoding gene Rspo2 was identified as a novel common integration site for the mouse mammary tumor virus in viral induced mouse mammary tumors. Rspo2 and Rspo2 / Wnt1 tumors contained many spindle cells, consistent with an epithelial-mesenchymal transformation phenotype. When Rspo2 and Rspo2 / Wnt1 tumor cells were transferred into naive mice, they exhibited greater metastatic activity than cells derived from Wnt1 tumors.

FTLS / RSPO2 Alternative Name

CRISTIN2, [homo-sapiens]
roof plate-specific spondin-2,R-spondin-2,CRISTIN2,R-spondin 2 homolog,UNQ9384/PRO34209, [human]
ftls,AA673245,D430027K22,2610028F08Rik, [mus-musculus]

FTLS / RSPO2 Related Studies

  • Cadieu E, et al. (2009) Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes. Science. 326: 150-153.
  • Kazanskaya O, et al. (2004) R-Spondin2 is a secreted activator of Wnt / beta-catenin signaling and is required for Xenopus myogenesis. Dev Cell. 7(4): 525-34.
  • Parker HG, et al. (2010) An insertion in the RSPO2 gene correlates with improper coat in the Portuguese water dog. J Hered. 101(5):612-7.
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