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Human FSTL1  Protein

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FSTL1
Expression host: Human Cells  
80885-H08H-50
80885-H08H-200
50 µg 
200 µg 
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Expression host: Human Cells  
10924-H08H-50
10924-H08H-100
50 µg 
100 µg 
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FSTL1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

FSTL1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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FSTL1 Summary & Protein Information

FSTL1 Related Information

FSTL1 Background

Gene Summary: FSTL1 gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. FSTL1 gene product is thought to be an autoantigen associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]
General information above from NCBI
Subunit structure: Interacts with SCN10A.
Subcellular location: Secreted {ECO:0000305}.
Tissue specificity: Overexpressed in synovial tissues from rheumatoid arthritis. {ECO:0000269|PubMed:15638044}.
Sequence similarity: Contains 2 EF-hand domains. {ECO:0000255|PROSITE-ProRule:PRU00448}.; Contains 1 follistatin-like domain. {ECO:0000305}.; Contains 1 Kazal-like domain. {ECO:0000255|PROSITE-ProRule:PRU00798}.; Contains 1 VWFC domain. {ECO:0000305}.
General information above from UniProt

Follistatin-related protein 1 (FSTL1)  is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here, we sought to identify the receptor that mediates the cellular actions of FSTL1. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. FSTL1 is thought to be an autoantigen associated with rheumatoid arthritis. DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. Experiment results have provided in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling.

FSTL1 Alternative Name

FRP,FSL1,MIR198, [homo-sapiens]
FLJ50214,FLJ52277,FRP,FSL1,FSTL1, [human]
AI316791,AW107808,Fstl,Fstl1,TSC-36, [mouse]
Fstl,TSC-36,AI316791,AW107808, [mus-musculus]

FSTL1 Related Studies

  • Rosenberg MI, et al. (2006) MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206. J Cell Biol. 175(1): 77-85.
  • Ouchi N, et al. (2010) DIP2A functions as a FSTL1 receptor. J Biol Chem. 285(10): 7127-34.
  • Geng Y, et al. (2011) Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proc Natl Acad Sci U S A. 108(17): 7058-63.
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