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Human FSTL1  Antibody

All FSTL1 Reagents

FSTL1
Reactivity: Human  
Application: 
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80885-T60-50
80885-T60-200
80885-T60-100
50 µg 
200 µg 
100 µg 
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Reactivity: Human  
Application: FCM  
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10924-R009-F-50
10924-R009-F-100
50 Tests 
100 Tests 
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Reactivity: Human  
Application: ELISA  
    10924-RP01-400
    10924-RP01-200
    10924-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    Reactivity: Human  
    Application: ELISA  
      10924-RP02-50
      10924-RP02-200
      10924-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        80885-RP01-400
        80885-RP01-200
        80885-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: IF  ICC/IF  
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        10924-R026-50
        10924-R026-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: FCM  IF  ICC/IF  
        • Slide 1
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        10924-R009-50
        10924-R009-100
        50 µg 
        100 µg 
        Add to Cart
        10924-H08HL-300 

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        FSTL1 Related Area

        FSTL1 Related Pathways

        FSTL1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

        FSTL1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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        FSTL1 Summary & Protein Information

        FSTL1 Related Information

        FSTL1 Background

        Gene Summary: FSTL1 gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. FSTL1 gene product is thought to be an autoantigen associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]
        General information above from NCBI
        Subunit structure: Interacts with SCN10A.
        Subcellular location: Secreted (Potential).
        Tissue specificity: Overexpressed in synovial tissues from rheumatoid arthritis.
        Sequence similarity: Contains 2 EF-hand domains.
        Contains 1 follistatin-like domain.
        Contains 1 Kazal-like domain.
        Contains 1 VWFC domain.C
        General information above from UniProt

        Follistatin-related protein 1 (FSTL1)  is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here, we sought to identify the receptor that mediates the cellular actions of FSTL1. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. FSTL1 is thought to be an autoantigen associated with rheumatoid arthritis. DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. Experiment results have provided in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling.

        FSTL1 Alternative Name

        FRP,FSL1,MIR198, [homo-sapiens]
        FLJ50214,FLJ52277,FRP,FSL1,FSTL1, [human]
        AI316791,AW107808,Fstl,Fstl1,TSC-36, [mouse]
        Fstl,TSC-36,AI316791,AW107808, [mus-musculus]

        FSTL1 Related Studies

      • Rosenberg MI, et al. (2006) MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206. J Cell Biol. 175(1): 77-85.
      • Ouchi N, et al. (2010) DIP2A functions as a FSTL1 receptor. J Biol Chem. 285(10): 7127-34.
      • Geng Y, et al. (2011) Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proc Natl Acad Sci U S A. 108(17): 7058-63.
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