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Human CNTF/Ciliary Neurotrophic Factor  Protein

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CNTF/Ciliary Neurotrophic Factor
Description: Active  
Expression host: E. coli  
11841-H07E-5
11841-H07E-20
11841-H07E-100
5 µg 
20 µg 
100 µg 
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    CNTF/Ciliary Neurotrophic Factor Summary & Protein Information

    CNTF/Ciliary Neurotrophic Factor Related Information

    CNTF/Ciliary Neurotrophic Factor Background

    Gene Summary: The protein encoded by CNTF gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]
    General information above from NCBI
    Subunit structure: Homodimer.
    Subcellular location: Cytoplasm.
    Tissue specificity: Nervous system.
    Sequence similarity: Belongs to the CNTF family. {ECO:0000305}.
    General information above from UniProt

    Ciliary neurotrophic factor (CNTF) is a member of the cytokine family. It is a polypeptide hormone that have functions in promoting neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. It's actions appear to be restricted to the nervous system. Ciliary neurotrophic factor (CNTF) has biological effects through the activation of a multi- subunit receptor complex, consisting of an extracelluar CNTF binding subunit (CNTFα) and two transmembrane signal transduction proteins: glycoprotein gp130 and LIF receptor. CNTF is considered as a potent survival factor of neurons and oligodendrocyteands may be relevant in reducing tissue destruction during inflammatory attacks. CNTF also is a survival factor for neurons of the peripheral sensory sympathetic and ciliary ganglia. It has been reported that CNTF could be an agent that has therapeutic potential and possibly induces differentiation of large multipolar ganglionic phenotype in a subset of progenitors.

    CNTF/Ciliary Neurotrophic Factor Alternative Name

    HCNTF, [homo-sapiens]
    CNTF,HCNTF, [human]
    AI429687,Cntf,MGC41235, [mouse]
    AI429687, [mus-musculus]

    CNTF/Ciliary Neurotrophic Factor Related Studies

  • Dutt K, et al. (2010) Ciliary neurotrophic factor: a survival and differentiation inducer in human retinal progenitors. In Vitro Cell Dev Biol Anim. 46 (7) : 635-46.
  • Lam A, et al.(1991) Sequence and structural organization of the human gene encoding ciliary neurotrophic factor. Gene 102 (2) : 271–6.
  • Bazan JF. ( 1991) Neuropoietic cytokines in the hematopoietic fold. Neuron 7 (2) : 197–208.
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